When Characteristics of Clinical Trials Require Per-Protocol as Well as Intention-to-Treat Outcomes to Draw Reliable Conclusions: Three Examples
Under exceptional circumstances, including high rates of protocol non-compliance, per-protocol (PP) analysis can better indicate the real-world benefits of a medical intervention than intention-to-treat (ITT) analysis. Exemplifying this, the first randomized clinical trial (RCT) considered found tha...
Main Authors: | Scheim, David E., Aldous, Colleen, Osimani, Barbara, Fordham, Edmund J., Hoy, Wendy E. |
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Format: | Article |
Published: |
Multidisciplinary Digital Publishing Institute
2023
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Online Access: | https://hdl.handle.net/1721.1/150888 |
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