Platforms for Biological Control
Innovation at the level of platforms provides the greatest leverage for shaping science and technology. Here, two key weaknesses in platforms for biology are addressed: the lack of accessible, extensible open-source software for the exploding field of robotic bioautomation, and the lack of a standar...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2023
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| Online Access: | https://hdl.handle.net/1721.1/151984 |
| _version_ | 1826197286283116544 |
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| author | Gretton, Dana |
| author2 | Esvelt, Kevin M. |
| author_facet | Esvelt, Kevin M. Gretton, Dana |
| author_sort | Gretton, Dana |
| collection | MIT |
| description | Innovation at the level of platforms provides the greatest leverage for shaping science and technology. Here, two key weaknesses in platforms for biology are addressed: the lack of accessible, extensible open-source software for the exploding field of robotic bioautomation, and the lack of a standardized, consistent screening platform for the manufacture of dangerous DNA. Pyhamilton and SecureDNA are introduced. Pyhamilton is the first open-source Python package for controlling Hamilton liquid-handling robots for biology. SecureDNA is the only DNA screening concept to prioritize anti-proliferation of pathogen genomes, and the first to employ modern cryptography to secure a global screening system that can keep up with anticipated exponential growth of the DNA synthesis market. For each platform developed, a software implementation is provided and exercised in a range of applications, and hardware demonstrators have been produced. |
| first_indexed | 2024-09-23T10:45:22Z |
| format | Thesis |
| id | mit-1721.1/151984 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:45:22Z |
| publishDate | 2023 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1519842023-09-01T03:40:26Z Platforms for Biological Control Gretton, Dana Esvelt, Kevin M. Program in Media Arts and Sciences (Massachusetts Institute of Technology) Innovation at the level of platforms provides the greatest leverage for shaping science and technology. Here, two key weaknesses in platforms for biology are addressed: the lack of accessible, extensible open-source software for the exploding field of robotic bioautomation, and the lack of a standardized, consistent screening platform for the manufacture of dangerous DNA. Pyhamilton and SecureDNA are introduced. Pyhamilton is the first open-source Python package for controlling Hamilton liquid-handling robots for biology. SecureDNA is the only DNA screening concept to prioritize anti-proliferation of pathogen genomes, and the first to employ modern cryptography to secure a global screening system that can keep up with anticipated exponential growth of the DNA synthesis market. For each platform developed, a software implementation is provided and exercised in a range of applications, and hardware demonstrators have been produced. S.M. 2023-08-30T15:56:31Z 2023-08-30T15:56:31Z 2022-09 2023-08-16T20:45:25.273Z Thesis https://hdl.handle.net/1721.1/151984 In Copyright - Educational Use Permitted Copyright MIT http://rightsstatements.org/page/InC-EDU/1.0/ application/pdf Massachusetts Institute of Technology |
| spellingShingle | Gretton, Dana Platforms for Biological Control |
| title | Platforms for Biological Control |
| title_full | Platforms for Biological Control |
| title_fullStr | Platforms for Biological Control |
| title_full_unstemmed | Platforms for Biological Control |
| title_short | Platforms for Biological Control |
| title_sort | platforms for biological control |
| url | https://hdl.handle.net/1721.1/151984 |
| work_keys_str_mv | AT grettondana platformsforbiologicalcontrol |