BRCA1 the Versatile Defender: Molecular to Environmental Perspectives
The evolving history of BRCA1 research demonstrates the profound interconnectedness of a single protein within the web of crucial functions in human cells. Mutations in BRCA1, a tumor suppressor gene, have been linked to heightened breast and ovarian cancer risks. However, despite decades of extensi...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | https://hdl.handle.net/1721.1/152287 |
| _version_ | 1811085859565338624 |
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| author | Zhong, Amy X. Chen, Yumay Chen, Phang-Lang |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Zhong, Amy X. Chen, Yumay Chen, Phang-Lang |
| author_sort | Zhong, Amy X. |
| collection | MIT |
| description | The evolving history of BRCA1 research demonstrates the profound interconnectedness of a single protein within the web of crucial functions in human cells. Mutations in BRCA1, a tumor suppressor gene, have been linked to heightened breast and ovarian cancer risks. However, despite decades of extensive research, the mechanisms underlying BRCA1’s contribution to tissue-specific tumor development remain elusive. Nevertheless, much of the BRCA1 protein’s structure, function, and interactions has been elucidated. Individual regions of BRCA1 interact with numerous proteins to play roles in ubiquitination, transcription, cell checkpoints, and DNA damage repair. At a cellular scale, these BRCA1 functions coordinate tumor suppression, R-loop prevention, and cellular differentiation, all of which may contribute to BRCA1’s role in cancer tissue specificity. As research on BRCA1 and breast cancer continues to evolve, it will become increasingly evident that modern materials such as Bisphenol A should be examined for their relationship with DNA stability, cancer incidence, and chemotherapy. Overall, this review offers a comprehensive understanding of BRCA1’s many roles at a molecular, cellular, organismal, and environmental scale. We hope that the knowledge gathered here highlights both the necessity of BRCA1 research and the potential for novel strategies to prevent and treat cancer in individuals carrying BRCA1 mutations. |
| first_indexed | 2024-09-23T13:16:40Z |
| format | Article |
| id | mit-1721.1/152287 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:16:40Z |
| publishDate | 2023 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | mit-1721.1/1522872024-01-22T17:38:08Z BRCA1 the Versatile Defender: Molecular to Environmental Perspectives Zhong, Amy X. Chen, Yumay Chen, Phang-Lang Harvard University--MIT Division of Health Sciences and Technology The evolving history of BRCA1 research demonstrates the profound interconnectedness of a single protein within the web of crucial functions in human cells. Mutations in BRCA1, a tumor suppressor gene, have been linked to heightened breast and ovarian cancer risks. However, despite decades of extensive research, the mechanisms underlying BRCA1’s contribution to tissue-specific tumor development remain elusive. Nevertheless, much of the BRCA1 protein’s structure, function, and interactions has been elucidated. Individual regions of BRCA1 interact with numerous proteins to play roles in ubiquitination, transcription, cell checkpoints, and DNA damage repair. At a cellular scale, these BRCA1 functions coordinate tumor suppression, R-loop prevention, and cellular differentiation, all of which may contribute to BRCA1’s role in cancer tissue specificity. As research on BRCA1 and breast cancer continues to evolve, it will become increasingly evident that modern materials such as Bisphenol A should be examined for their relationship with DNA stability, cancer incidence, and chemotherapy. Overall, this review offers a comprehensive understanding of BRCA1’s many roles at a molecular, cellular, organismal, and environmental scale. We hope that the knowledge gathered here highlights both the necessity of BRCA1 research and the potential for novel strategies to prevent and treat cancer in individuals carrying BRCA1 mutations. 2023-09-27T20:12:12Z 2023-09-27T20:12:12Z 2023-09-19 2023-09-27T12:36:14Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/152287 International Journal of Molecular Sciences 24 (18): 14276 (2023) PUBLISHER_CC http://dx.doi.org/10.3390/ijms241814276 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Multidisciplinary Digital Publishing Institute |
| spellingShingle | Zhong, Amy X. Chen, Yumay Chen, Phang-Lang BRCA1 the Versatile Defender: Molecular to Environmental Perspectives |
| title | BRCA1 the Versatile Defender: Molecular to Environmental Perspectives |
| title_full | BRCA1 the Versatile Defender: Molecular to Environmental Perspectives |
| title_fullStr | BRCA1 the Versatile Defender: Molecular to Environmental Perspectives |
| title_full_unstemmed | BRCA1 the Versatile Defender: Molecular to Environmental Perspectives |
| title_short | BRCA1 the Versatile Defender: Molecular to Environmental Perspectives |
| title_sort | brca1 the versatile defender molecular to environmental perspectives |
| url | https://hdl.handle.net/1721.1/152287 |
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