Design principles of 3D epigenetic memory systems
<jats:p>Cells remember their identities, in part, by using epigenetic marks—chemical modifications placed along the genome. How can mark patterns remain stable over cell generations despite their constant erosion by replication and other processes? We developed a theoretical model that reveals...
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2023
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| Online Access: | https://hdl.handle.net/1721.1/153004 |
| _version_ | 1826191278475313152 |
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| author | Owen, Jeremy A. Osmanović, Dino Mirny, Leonid |
| author2 | Massachusetts Institute of Technology. Department of Physics |
| author_facet | Massachusetts Institute of Technology. Department of Physics Owen, Jeremy A. Osmanović, Dino Mirny, Leonid |
| author_sort | Owen, Jeremy A. |
| collection | MIT |
| description | <jats:p>Cells remember their identities, in part, by using epigenetic marks—chemical modifications placed along the genome. How can mark patterns remain stable over cell generations despite their constant erosion by replication and other processes? We developed a theoretical model that reveals that three-dimensional (3D) genome organization can stabilize epigenetic memory as long as (i) there is a large density difference between chromatin compartments, (ii) modifying “reader-writer” enzymes spread marks in three dimensions, and (iii) the enzymes are limited in abundance relative to their histone substrates. Analogous to an associative memory that encodes memory in neuronal connectivity, mark patterns are encoded in a 3D network of chromosomal contacts. Our model provides a unified account of diverse observations and reveals a key role of 3D genome organization in epigenetic memory.</jats:p> |
| first_indexed | 2024-09-23T08:53:45Z |
| format | Article |
| id | mit-1721.1/153004 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:53:45Z |
| publishDate | 2023 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1530042023-11-18T03:49:45Z Design principles of 3D epigenetic memory systems Owen, Jeremy A. Osmanović, Dino Mirny, Leonid Massachusetts Institute of Technology. Department of Physics Multidisciplinary <jats:p>Cells remember their identities, in part, by using epigenetic marks—chemical modifications placed along the genome. How can mark patterns remain stable over cell generations despite their constant erosion by replication and other processes? We developed a theoretical model that reveals that three-dimensional (3D) genome organization can stabilize epigenetic memory as long as (i) there is a large density difference between chromatin compartments, (ii) modifying “reader-writer” enzymes spread marks in three dimensions, and (iii) the enzymes are limited in abundance relative to their histone substrates. Analogous to an associative memory that encodes memory in neuronal connectivity, mark patterns are encoded in a 3D network of chromosomal contacts. Our model provides a unified account of diverse observations and reveals a key role of 3D genome organization in epigenetic memory.</jats:p> 2023-11-17T19:10:48Z 2023-11-17T19:10:48Z 2023-11-17 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 https://hdl.handle.net/1721.1/153004 Owen, Jeremy A., Osmanović, Dino and Mirny, Leonid. 2023. "Design principles of 3D epigenetic memory systems." Science, 382 (6672). en_US 10.1126/science.adg3053 Science Creative Commons Attribution-Noncommercial-Share Alike An error occurred on the license name. https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) MIT News office |
| spellingShingle | Multidisciplinary Owen, Jeremy A. Osmanović, Dino Mirny, Leonid Design principles of 3D epigenetic memory systems |
| title | Design principles of 3D epigenetic memory systems |
| title_full | Design principles of 3D epigenetic memory systems |
| title_fullStr | Design principles of 3D epigenetic memory systems |
| title_full_unstemmed | Design principles of 3D epigenetic memory systems |
| title_short | Design principles of 3D epigenetic memory systems |
| title_sort | design principles of 3d epigenetic memory systems |
| topic | Multidisciplinary |
| url | https://hdl.handle.net/1721.1/153004 |
| work_keys_str_mv | AT owenjeremya designprinciplesof3depigeneticmemorysystems AT osmanovicdino designprinciplesof3depigeneticmemorysystems AT mirnyleonid designprinciplesof3depigeneticmemorysystems |