An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation
Precise neurostimulation has potential to revolutionize therapies for neurological disorders. However, current neural interfaces targeting the deep brain face significant limitations in spatial resolution and potency due to tissue attenuation. We developed an implantable piezoelectric ultrasound sti...
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| Other Authors: | |
| Format: | Thesis |
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/153341 https://orcid.org/0000-0001-9131-9583 |
| _version_ | 1826209918089166848 |
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| author | Hou, Jason F. |
| author2 | Dagdeviren, Canan |
| author_facet | Dagdeviren, Canan Hou, Jason F. |
| author_sort | Hou, Jason F. |
| collection | MIT |
| description | Precise neurostimulation has potential to revolutionize therapies for neurological disorders. However, current neural interfaces targeting the deep brain face significant limitations in spatial resolution and potency due to tissue attenuation. We developed an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal point pressure of 100 kPa and can non-genetically modulate the activity of neurons. We demonstrated that ImPULS can i) excite neurons in a mouse hippocampal slice ex vivo, ii) activate cells in the hippocampus of an anesthetized mouse to induce expression of activity-dependent gene c-Fos, and iii) stimulate dopaminergic neurons in the substantia nigra pars compacta (SNc) to elicit time-locked modulation of nigrostriatal dopamine release. This work introduces a novel, non-genetic ultrasound platform for spatially localized neural stimulation. |
| first_indexed | 2024-09-23T14:35:21Z |
| format | Thesis |
| id | mit-1721.1/153341 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:35:21Z |
| publishDate | 2024 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1533412024-01-17T03:18:24Z An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation Hou, Jason F. Dagdeviren, Canan Program in Media Arts and Sciences (Massachusetts Institute of Technology) Precise neurostimulation has potential to revolutionize therapies for neurological disorders. However, current neural interfaces targeting the deep brain face significant limitations in spatial resolution and potency due to tissue attenuation. We developed an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal point pressure of 100 kPa and can non-genetically modulate the activity of neurons. We demonstrated that ImPULS can i) excite neurons in a mouse hippocampal slice ex vivo, ii) activate cells in the hippocampus of an anesthetized mouse to induce expression of activity-dependent gene c-Fos, and iii) stimulate dopaminergic neurons in the substantia nigra pars compacta (SNc) to elicit time-locked modulation of nigrostriatal dopamine release. This work introduces a novel, non-genetic ultrasound platform for spatially localized neural stimulation. S.M. 2024-01-16T21:52:31Z 2024-01-16T21:52:31Z 2023-06 2023-08-16T20:34:14.683Z Thesis https://hdl.handle.net/1721.1/153341 https://orcid.org/0000-0001-9131-9583 In Copyright - Educational Use Permitted Copyright retained by author(s) https://rightsstatements.org/page/InC-EDU/1.0/ application/pdf Massachusetts Institute of Technology |
| spellingShingle | Hou, Jason F. An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation |
| title | An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation |
| title_full | An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation |
| title_fullStr | An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation |
| title_full_unstemmed | An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation |
| title_short | An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation |
| title_sort | implantable piezoelectric ultrasound stimulator impuls for selective deep brain activation |
| url | https://hdl.handle.net/1721.1/153341 https://orcid.org/0000-0001-9131-9583 |
| work_keys_str_mv | AT houjasonf animplantablepiezoelectricultrasoundstimulatorimpulsforselectivedeepbrainactivation AT houjasonf implantablepiezoelectricultrasoundstimulatorimpulsforselectivedeepbrainactivation |