Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing

Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing

Sequence-specific RNA-binding proteins (RBPs) play central roles in splicing decisions. Here, we describe a modular splicing architecture that leverages in vitro-derived RNA affinity models for 79 human RBPs and the annotated human genome to produce improved models of RBP binding and activity. Bindi...

Full description

Bibliographic Details
Main Authors: Gupta, Kavi, Yang, Chenxi, McCue, Kayla, Bastani, Osbert, Sharp, Phillip A., Burge, Christopher B., Solar-Lezama, Armando
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Language:English
Published: BioMed Central 2024
Online Access:https://hdl.handle.net/1721.1/153401

Internet

https://hdl.handle.net/1721.1/153401

Similar Items