Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing
Sequence-specific RNA-binding proteins (RBPs) play central roles in splicing decisions. Here, we describe a modular splicing architecture that leverages in vitro-derived RNA affinity models for 79 human RBPs and the annotated human genome to produce improved models of RBP binding and activity. Bindi...
Main Authors: | Gupta, Kavi, Yang, Chenxi, McCue, Kayla, Bastani, Osbert, Sharp, Phillip A., Burge, Christopher B., Solar-Lezama, Armando |
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Other Authors: | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
Format: | Article |
Language: | English |
Published: |
BioMed Central
2024
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Online Access: | https://hdl.handle.net/1721.1/153401 |
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