Brainstem control of vocalization and its coordination with respiration
Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific laryngeal premotor neurons located in the retroambiguus nucleus (RAm...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Association for the Advancement of Science
2024
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| Online Access: | https://hdl.handle.net/1721.1/153639 |
| _version_ | 1811082272729726976 |
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| author | Park, Jaehong Choi, Seonmi Takatoh, Jun Zhao, Shengli Harrahill, Andrew Han, Bao-Xia Wang, Fan |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Park, Jaehong Choi, Seonmi Takatoh, Jun Zhao, Shengli Harrahill, Andrew Han, Bao-Xia Wang, Fan |
| author_sort | Park, Jaehong |
| collection | MIT |
| description | Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific laryngeal premotor neurons located in the retroambiguus nucleus (RAmVOC) in adult mice as both necessary and sufficient for driving vocal cord closure and eliciting mouse ultrasonic vocalizations (USVs). The duration of RAmVOC activation can determine the lengths of both USV syllables and concurrent expiration periods, with the impact of RAmVOC-activation depending on respiration phases. RAmVOC-neurons receive inhibition from the preBötzinger complex, and inspiration-needs override RAmVOC-mediated vocal-cord closure. Ablating inhibitory synapses in RAmVOC-neurons compromised this inspiration gating of laryngeal adduction, resulting in discoordination of vocalization with respiration. Our study revealed the circuits for vocal production and vocal-respiratory coordination. |
| first_indexed | 2024-09-23T12:00:29Z |
| format | Article |
| id | mit-1721.1/153639 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:00:29Z |
| publishDate | 2024 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | mit-1721.1/1536392024-03-08T03:37:19Z Brainstem control of vocalization and its coordination with respiration Park, Jaehong Choi, Seonmi Takatoh, Jun Zhao, Shengli Harrahill, Andrew Han, Bao-Xia Wang, Fan Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific laryngeal premotor neurons located in the retroambiguus nucleus (RAmVOC) in adult mice as both necessary and sufficient for driving vocal cord closure and eliciting mouse ultrasonic vocalizations (USVs). The duration of RAmVOC activation can determine the lengths of both USV syllables and concurrent expiration periods, with the impact of RAmVOC-activation depending on respiration phases. RAmVOC-neurons receive inhibition from the preBötzinger complex, and inspiration-needs override RAmVOC-mediated vocal-cord closure. Ablating inhibitory synapses in RAmVOC-neurons compromised this inspiration gating of laryngeal adduction, resulting in discoordination of vocalization with respiration. Our study revealed the circuits for vocal production and vocal-respiratory coordination. 2024-03-07T17:52:51Z 2024-03-07T17:52:51Z 2024-02-07 Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/153639 Park, Jaehong, Choi, Seonmi, Takatoh, Jun, Zhao, Shengli, Harrahill, Andrew et al. 2024. "Brainstem control of vocalization and its coordination with respiration." Science. 10.1126/science.adi8081 en_US Science Creative Commons Attribution-Noncommercial-ShareAlike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science MIT News |
| spellingShingle | Park, Jaehong Choi, Seonmi Takatoh, Jun Zhao, Shengli Harrahill, Andrew Han, Bao-Xia Wang, Fan Brainstem control of vocalization and its coordination with respiration |
| title | Brainstem control of vocalization and its coordination with respiration |
| title_full | Brainstem control of vocalization and its coordination with respiration |
| title_fullStr | Brainstem control of vocalization and its coordination with respiration |
| title_full_unstemmed | Brainstem control of vocalization and its coordination with respiration |
| title_short | Brainstem control of vocalization and its coordination with respiration |
| title_sort | brainstem control of vocalization and its coordination with respiration |
| url | https://hdl.handle.net/1721.1/153639 |
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