Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor
Perfluoroalkyl substances (PFAS), known as “forever chemicals,” are a growing concern in the sphere of human and environmental health. In response, rapid, reproducible, and inexpensive methods for PFAS detection in the environment and home water supplies are needed. We have developed a simple and in...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
PNAS
2024
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| Online Access: | https://hdl.handle.net/1721.1/153648 |
| _version_ | 1826200690276433920 |
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| author | Park, Sohyun Gordon, Collette T. Swager, Timothy M. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Park, Sohyun Gordon, Collette T. Swager, Timothy M. |
| author_sort | Park, Sohyun |
| collection | MIT |
| description | Perfluoroalkyl substances (PFAS), known as “forever chemicals,” are a growing concern in the sphere of human and environmental health. In response, rapid, reproducible, and inexpensive methods for PFAS detection in the environment and home water supplies are needed. We have developed a simple and inexpensive perfluoroalkyl acid detection method based on an electrically read lateral flow assay (e-LFA). Our method employs a new fluorous surfactant formulation with undoped polyaniline (F-PANI) fabricated to create test lines for the lateral flow assay. In perfluoroalkyl acid sensing studies, an increase in conductivity of the F-PANI film is caused by acidification and doping of PANI. A conductivity enhancement by 104-fold can be produced by this method and we demonstrate a limit of detection for perfluorooctanoic acid (PFOA) of 400 ppt and perfluorobutanoic acid (PFBA) of 200 ppt. This new method for PFOA detection can be expanded for wide-scale environmental and at-home water testing. |
| first_indexed | 2024-09-23T11:40:20Z |
| format | Article |
| id | mit-1721.1/153648 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:40:20Z |
| publishDate | 2024 |
| publisher | PNAS |
| record_format | dspace |
| spelling | mit-1721.1/1536482024-03-12T03:38:29Z Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor Park, Sohyun Gordon, Collette T. Swager, Timothy M. Massachusetts Institute of Technology. Department of Chemistry Perfluoroalkyl substances (PFAS), known as “forever chemicals,” are a growing concern in the sphere of human and environmental health. In response, rapid, reproducible, and inexpensive methods for PFAS detection in the environment and home water supplies are needed. We have developed a simple and inexpensive perfluoroalkyl acid detection method based on an electrically read lateral flow assay (e-LFA). Our method employs a new fluorous surfactant formulation with undoped polyaniline (F-PANI) fabricated to create test lines for the lateral flow assay. In perfluoroalkyl acid sensing studies, an increase in conductivity of the F-PANI film is caused by acidification and doping of PANI. A conductivity enhancement by 104-fold can be produced by this method and we demonstrate a limit of detection for perfluorooctanoic acid (PFOA) of 400 ppt and perfluorobutanoic acid (PFBA) of 200 ppt. This new method for PFOA detection can be expanded for wide-scale environmental and at-home water testing. 2024-03-11T14:24:04Z 2024-03-11T14:24:04Z 2024-03-11 Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/153648 Park, Sohyun, Gordon, Collette T. and Swager, Timothy M. 2024. "Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor." PNAS. en_US PNAS Creative Commons Attribution-Noncommercial-ShareAlike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf PNAS MIT News |
| spellingShingle | Park, Sohyun Gordon, Collette T. Swager, Timothy M. Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor |
| title | Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor |
| title_full | Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor |
| title_fullStr | Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor |
| title_full_unstemmed | Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor |
| title_short | Resistivity Detection of Perfluoroalkyl Substances (PFAS) with 6 Fluorous-Polyaniline in an Electrical Lateral Flow Sensor |
| title_sort | resistivity detection of perfluoroalkyl substances pfas with 6 fluorous polyaniline in an electrical lateral flow sensor |
| url | https://hdl.handle.net/1721.1/153648 |
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