Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study
The spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To overcome this, we designed an empirical unified shim–RF h...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
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MDPI AG
2024
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| Online Access: | https://hdl.handle.net/1721.1/153953 |
| _version_ | 1811075581826039808 |
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| author | Malagi, Archana Vadiraj Li, Xinqi Zhang, Na Liu, Yucen Huang, Yuheng Serry, Fardad Michael Long, Ziyang Yang, Chia-Chi Shan, Yujie Cai, Yubin Zepeda, Jeremy Binesh, Nader Li, Debiao Yang, Hsin-Jung Han, Hui |
| author_facet | Malagi, Archana Vadiraj Li, Xinqi Zhang, Na Liu, Yucen Huang, Yuheng Serry, Fardad Michael Long, Ziyang Yang, Chia-Chi Shan, Yujie Cai, Yubin Zepeda, Jeremy Binesh, Nader Li, Debiao Yang, Hsin-Jung Han, Hui |
| author_sort | Malagi, Archana Vadiraj |
| collection | MIT |
| description | The spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To overcome this, we designed an empirical unified shim–RF head coil (32-ch RF receive and 51-ch shim) for 3D-MRSI improvement. We compared its shimming performance and 3D-MRSI brain coverages against the standard scanner shim (2nd-order spherical harmonic (SH) shim coils) and integrated parallel reception, excitation, and shimming (iPRES) 32-ch AC/DC head coil. We also simulated a theoretical 3rd-, 4th-, and 5th-order SH shim as a benchmark to assess the UNIfied shim–RF coil (UNIC) improvements. In this preliminary study, the whole-brain coverage was simulated by using B0 field maps of twenty-four healthy human subjects (n = 24). Our results demonstrated that UNIC substantially improves brain field homogeneity, reducing whole-brain frequency standard deviations by 27% compared to the standard 2nd-order scanner shim and 17% compared to the iPRES shim. Moreover, UNIC enhances whole-brain coverage of 3D-MRSI by up to 34% compared to the standard 2nd-order scanner shim and up to 13% compared to the iPRES shim. UNIC markedly increases coverage in the prefrontal cortex by 147% and 47% and in the medial temporal lobe and temporal pole by 29% and 13%, respectively, at voxel resolutions of 1.4 cc and 0.09 cc for 3D-MRSI. Furthermore, UNIC effectively reduces variations in shim quality and brain coverage among different subjects compared to scanner shim and iPRES shim. Anticipated advancements in higher-order shimming (beyond 6th order) are expected via optimized designs using dimensionality reduction methods. |
| first_indexed | 2024-09-23T10:08:46Z |
| format | Article |
| id | mit-1721.1/153953 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:08:46Z |
| publishDate | 2024 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/1539532024-04-20T06:07:58Z Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study Malagi, Archana Vadiraj Li, Xinqi Zhang, Na Liu, Yucen Huang, Yuheng Serry, Fardad Michael Long, Ziyang Yang, Chia-Chi Shan, Yujie Cai, Yubin Zepeda, Jeremy Binesh, Nader Li, Debiao Yang, Hsin-Jung Han, Hui Cancer Research Oncology The spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To overcome this, we designed an empirical unified shim–RF head coil (32-ch RF receive and 51-ch shim) for 3D-MRSI improvement. We compared its shimming performance and 3D-MRSI brain coverages against the standard scanner shim (2nd-order spherical harmonic (SH) shim coils) and integrated parallel reception, excitation, and shimming (iPRES) 32-ch AC/DC head coil. We also simulated a theoretical 3rd-, 4th-, and 5th-order SH shim as a benchmark to assess the UNIfied shim–RF coil (UNIC) improvements. In this preliminary study, the whole-brain coverage was simulated by using B0 field maps of twenty-four healthy human subjects (n = 24). Our results demonstrated that UNIC substantially improves brain field homogeneity, reducing whole-brain frequency standard deviations by 27% compared to the standard 2nd-order scanner shim and 17% compared to the iPRES shim. Moreover, UNIC enhances whole-brain coverage of 3D-MRSI by up to 34% compared to the standard 2nd-order scanner shim and up to 13% compared to the iPRES shim. UNIC markedly increases coverage in the prefrontal cortex by 147% and 47% and in the medial temporal lobe and temporal pole by 29% and 13%, respectively, at voxel resolutions of 1.4 cc and 0.09 cc for 3D-MRSI. Furthermore, UNIC effectively reduces variations in shim quality and brain coverage among different subjects compared to scanner shim and iPRES shim. Anticipated advancements in higher-order shimming (beyond 6th order) are expected via optimized designs using dimensionality reduction methods. 2024-03-27T16:11:53Z 2024-03-27T16:11:53Z 2024-03-21 2024-03-27T13:15:53Z Article http://purl.org/eprint/type/JournalArticle 2072-6694 https://hdl.handle.net/1721.1/153953 Cancers 16 (6): 1233 (2024) PUBLISHER_CC 10.3390/cancers16061233 Cancers Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf MDPI AG Multidisciplinary Digital Publishing Institute |
| spellingShingle | Cancer Research Oncology Malagi, Archana Vadiraj Li, Xinqi Zhang, Na Liu, Yucen Huang, Yuheng Serry, Fardad Michael Long, Ziyang Yang, Chia-Chi Shan, Yujie Cai, Yubin Zepeda, Jeremy Binesh, Nader Li, Debiao Yang, Hsin-Jung Han, Hui Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_full | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_fullStr | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_full_unstemmed | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_short | Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study |
| title_sort | enhancing whole brain magnetic field homogeneity for 3d magnetic resonance spectroscopic imaging with a novel unified coil a preliminary study |
| topic | Cancer Research Oncology |
| url | https://hdl.handle.net/1721.1/153953 |
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