Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application
Medical imaging techniques are being increasingly used to derive quantitative information, requiring a new type of imaging phantom for validation. Here, we describe the T2 relaxation properties of an emulsified two-phase imaging phantom for validating a nuclear magnetic resonance (NMR) sensor for me...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/153996 |
| _version_ | 1826207651516645376 |
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| author | Khatun, Amena |
| author2 | Cima, Michael |
| author_facet | Cima, Michael Khatun, Amena |
| author_sort | Khatun, Amena |
| collection | MIT |
| description | Medical imaging techniques are being increasingly used to derive quantitative information, requiring a new type of imaging phantom for validation. Here, we describe the T2 relaxation properties of an emulsified two-phase imaging phantom for validating a nuclear magnetic resonance (NMR) sensor for measuring fluid volume in vivo. The phantoms simulate muscle and subcutaneous adipose tissues (SCAT) and assure the repeatability and accuracy of the technique. We determined that the 40% phantoms model muscle tissue and 70% model SCAT. The microstructure of the 40% phantoms was changed by controlling temperature and stir rate. Lower temperature and stir rate produced phantoms with a significantly larger average droplet size than higher temperature and stir rate. Microstructure changes did not alter the T2 relaxation behavior (p = 0.05) but altered relative diffusion time. We changed the fabrication protocol by comparing reagent-grade peanut oil to cooking-grade peanut oil and creating the water and lipid phases separately versus together. There was no significant difference (p = 0.05) in T2 relaxation of the 40% and 70%. The phantoms are stable, robust, and reproducible. |
| first_indexed | 2024-09-23T13:52:50Z |
| format | Thesis |
| id | mit-1721.1/153996 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:52:50Z |
| publishDate | 2024 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1539962024-04-03T03:29:30Z Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application Khatun, Amena Cima, Michael Massachusetts Institute of Technology. Department of Materials Science and Engineering Medical imaging techniques are being increasingly used to derive quantitative information, requiring a new type of imaging phantom for validation. Here, we describe the T2 relaxation properties of an emulsified two-phase imaging phantom for validating a nuclear magnetic resonance (NMR) sensor for measuring fluid volume in vivo. The phantoms simulate muscle and subcutaneous adipose tissues (SCAT) and assure the repeatability and accuracy of the technique. We determined that the 40% phantoms model muscle tissue and 70% model SCAT. The microstructure of the 40% phantoms was changed by controlling temperature and stir rate. Lower temperature and stir rate produced phantoms with a significantly larger average droplet size than higher temperature and stir rate. Microstructure changes did not alter the T2 relaxation behavior (p = 0.05) but altered relative diffusion time. We changed the fabrication protocol by comparing reagent-grade peanut oil to cooking-grade peanut oil and creating the water and lipid phases separately versus together. There was no significant difference (p = 0.05) in T2 relaxation of the 40% and 70%. The phantoms are stable, robust, and reproducible. S.B. 2024-04-02T14:54:35Z 2024-04-02T14:54:35Z 2023-06 2024-03-25T16:00:07.081Z Thesis https://hdl.handle.net/1721.1/153996 In Copyright - Educational Use Permitted Copyright retained by author(s) https://rightsstatements.org/page/InC-EDU/1.0/ application/pdf Massachusetts Institute of Technology |
| spellingShingle | Khatun, Amena Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application |
| title | Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application |
| title_full | Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application |
| title_fullStr | Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application |
| title_full_unstemmed | Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application |
| title_short | Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application |
| title_sort | characterizing muscle and subcutaneous adipose tissue imaging phantoms for nmr application |
| url | https://hdl.handle.net/1721.1/153996 |
| work_keys_str_mv | AT khatunamena characterizingmuscleandsubcutaneousadiposetissueimagingphantomsfornmrapplication |