UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION
Proceedings of the 2023 Design of Medical Devices Conference DMD2023 April 17-19, 2023, Minneapolis, MN, USA
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Society of Mechanical Engineers
2024
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| Online Access: | https://hdl.handle.net/1721.1/154100 |
| _version_ | 1824458118900219904 |
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| author | Reddie, Madison Eberly, Gari Jesse Levi, Aviva Quevedo-Moreno, Diego Mendez, Keegan Roche, Ellen T. |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Reddie, Madison Eberly, Gari Jesse Levi, Aviva Quevedo-Moreno, Diego Mendez, Keegan Roche, Ellen T. |
| author_sort | Reddie, Madison |
| collection | MIT |
| description | Proceedings of the 2023 Design of Medical Devices Conference DMD2023 April 17-19, 2023, Minneapolis, MN, USA |
| first_indexed | 2024-09-23T11:54:32Z |
| format | Article |
| id | mit-1721.1/154100 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:20:49Z |
| publishDate | 2024 |
| publisher | American Society of Mechanical Engineers |
| record_format | dspace |
| spelling | mit-1721.1/1541002025-01-05T04:49:42Z UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION Reddie, Madison Eberly, Gari Jesse Levi, Aviva Quevedo-Moreno, Diego Mendez, Keegan Roche, Ellen T. Massachusetts Institute of Technology. Department of Mechanical Engineering Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Institute for Medical Engineering & Science Proceedings of the 2023 Design of Medical Devices Conference DMD2023 April 17-19, 2023, Minneapolis, MN, USA Blood clots originating in the left atrial appendage (LAA) are the leading cause of ischemic stroke in patients with nonvalvular atrial fibrillation (AF). Complications from and contraindications to oral anticoagulants (OACs), in addition to the recent successes of endocardial LAA closure devices, have driven increased interest in mechanical LAA occlusion. However, current devices are limited in their abilities to accommodate diverse LAA anatomies, motivating the development of a novel endocardial LAA occluder that supports more anatomical variability. We present the design of an in-situ expandable plug as well as an accompanying pacifier module for LAA occlusion. The final design accommodates LAA diameter ranges of 14 millimeters for each device size (10-24mm and 24-38mm), double that of any approved device. This adaptability can help to overcome imperfect pre-procedural imaging and suboptimal device fit. Benchtop tug and leak tests demonstrate the stability and sealing capacities of the design. 2024-04-09T16:22:05Z 2024-04-09T16:22:05Z 2023-04-17 2024-04-09T16:08:46Z Article http://purl.org/eprint/type/ConferencePaper https://hdl.handle.net/1721.1/154100 Reddie, M, Eberly, G, Jesse Levi, A, Quevedo-Moreno, D, Mendez, K, & Roche, ET. "UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION." Proceedings of the 2023 Design of Medical Devices Conference. 2023 Design of Medical Devices Conference. Minneapolis, MN, USA. April 17–19, 2023. V001T01A001. ASME. en 10.1115/dmd2023-1984 2023 Design of Medical Devices Conference Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Society of Mechanical Engineers American Society of Mechanical Engineers |
| spellingShingle | Reddie, Madison Eberly, Gari Jesse Levi, Aviva Quevedo-Moreno, Diego Mendez, Keegan Roche, Ellen T. UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION |
| title | UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION |
| title_full | UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION |
| title_fullStr | UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION |
| title_full_unstemmed | UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION |
| title_short | UMBRELAA: DESIGN OF A VARIABLE-SIZED LEFT ATRIAL APPENDAGE OCCLUSION DEVICE FOR STROKE PREVENTION |
| title_sort | umbrelaa design of a variable sized left atrial appendage occlusion device for stroke prevention |
| url | https://hdl.handle.net/1721.1/154100 |
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