Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function
The treatment of end-stage heart failure has evolved substantially with advances in medical treatment, cardiac transplantation, and mechanical circulatory support (MCS) devices such as left ventricular assist devices and total artificial hearts. However, current MCS devices are inherently blood cont...
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| Format: | Article |
| Language: | English |
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Annual Reviews
2024
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| Online Access: | https://hdl.handle.net/1721.1/154106 |
| _version_ | 1826216938465918976 |
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| author | Bonnemain, Jean del Nido, Pedro J. Roche, Ellen T. |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Bonnemain, Jean del Nido, Pedro J. Roche, Ellen T. |
| author_sort | Bonnemain, Jean |
| collection | MIT |
| description | The treatment of end-stage heart failure has evolved substantially with advances in medical treatment, cardiac transplantation, and mechanical circulatory support (MCS) devices such as left ventricular assist devices and total artificial hearts. However, current MCS devices are inherently blood contacting and can lead to potential complications including pump thrombosis, hemorrhage, stroke, and hemolysis. Attempts to address these issues and avoid blood contact led to the concept of compressing the failing heart from the epicardial surface and the design of direct cardiac compression (DCC) devices. We review the fundamental concepts related to DCC, present the foundational devices and recent devices in the research and commercialization stages, and discuss the milestones required for clinical translation and adoption of this technology. |
| first_indexed | 2024-09-23T16:55:33Z |
| format | Article |
| id | mit-1721.1/154106 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:25:57Z |
| publishDate | 2024 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | mit-1721.1/1541062025-01-06T04:11:30Z Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function Bonnemain, Jean del Nido, Pedro J. Roche, Ellen T. Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Mechanical Engineering Biomedical Engineering Medicine (miscellaneous) The treatment of end-stage heart failure has evolved substantially with advances in medical treatment, cardiac transplantation, and mechanical circulatory support (MCS) devices such as left ventricular assist devices and total artificial hearts. However, current MCS devices are inherently blood contacting and can lead to potential complications including pump thrombosis, hemorrhage, stroke, and hemolysis. Attempts to address these issues and avoid blood contact led to the concept of compressing the failing heart from the epicardial surface and the design of direct cardiac compression (DCC) devices. We review the fundamental concepts related to DCC, present the foundational devices and recent devices in the research and commercialization stages, and discuss the milestones required for clinical translation and adoption of this technology. 2024-04-10T16:08:07Z 2024-04-10T16:08:07Z 2022-06-06 2024-04-10T15:57:24Z Article http://purl.org/eprint/type/JournalArticle 1523-9829 1545-4274 https://hdl.handle.net/1721.1/154106 Bonnemain, Jean, del Nido, Pedro J. and Roche, Ellen T. 2022. "Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function." Annual Review of Biomedical Engineering, 24 (1). en 10.1146/annurev-bioeng-110220-025309 Annual Review of Biomedical Engineering Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Annual Reviews Annual Reviews |
| spellingShingle | Biomedical Engineering Medicine (miscellaneous) Bonnemain, Jean del Nido, Pedro J. Roche, Ellen T. Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function |
| title | Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function |
| title_full | Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function |
| title_fullStr | Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function |
| title_full_unstemmed | Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function |
| title_short | Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function |
| title_sort | direct cardiac compression devices to augment heart biomechanics and function |
| topic | Biomedical Engineering Medicine (miscellaneous) |
| url | https://hdl.handle.net/1721.1/154106 |
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