Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management
The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death b...
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| Format: | Article |
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MDPI AG
2024
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| Online Access: | https://hdl.handle.net/1721.1/154126 |
| _version_ | 1811071489622933504 |
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| author | Viana Cabral, Fernanda Quilez Alburquerque, Jose Roberts, Harrison James Hasan, Tayyaba |
| author_facet | Viana Cabral, Fernanda Quilez Alburquerque, Jose Roberts, Harrison James Hasan, Tayyaba |
| author_sort | Viana Cabral, Fernanda |
| collection | MIT |
| description | The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. This review explores the principles of PDT and discusses the concept of photodynamic priming (PDP), which augments the effectiveness of treatments like chemotherapy. Furthermore, the integration of nanotechnology for precise drug delivery at the right time and location and PDT optimization are examined. Ultimately, this study highlights the potential and limitations of PDT and PDP in cancer treatment paradigms, offering insights into future clinical applications. |
| first_indexed | 2024-09-23T08:51:56Z |
| format | Article |
| id | mit-1721.1/154126 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:51:56Z |
| publishDate | 2024 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/1541262024-04-28T05:04:42Z Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management Viana Cabral, Fernanda Quilez Alburquerque, Jose Roberts, Harrison James Hasan, Tayyaba Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. This review explores the principles of PDT and discusses the concept of photodynamic priming (PDP), which augments the effectiveness of treatments like chemotherapy. Furthermore, the integration of nanotechnology for precise drug delivery at the right time and location and PDT optimization are examined. Ultimately, this study highlights the potential and limitations of PDT and PDP in cancer treatment paradigms, offering insights into future clinical applications. 2024-04-12T14:12:13Z 2024-04-12T14:12:13Z 2024-03-29 2024-04-12T13:14:22Z Article http://purl.org/eprint/type/JournalArticle 1422-0067 https://hdl.handle.net/1721.1/154126 Viana Cabral F, Quilez Alburquerque J, Roberts HJ, Hasan T. Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management. International Journal of Molecular Sciences. 2024; 25(7):3811. PUBLISHER_CC 10.3390/ijms25073811 International Journal of Molecular Sciecnes Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf MDPI AG Multidisciplinary Digital Publishing Institute |
| spellingShingle | Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis Viana Cabral, Fernanda Quilez Alburquerque, Jose Roberts, Harrison James Hasan, Tayyaba Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management |
| title | Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management |
| title_full | Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management |
| title_fullStr | Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management |
| title_full_unstemmed | Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management |
| title_short | Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management |
| title_sort | shedding light on chemoresistance the perspective of photodynamic therapy in cancer management |
| topic | Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
| url | https://hdl.handle.net/1721.1/154126 |
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