Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release
Traditional implanted drug delivery systems cannot easily change their release profile in real time to respond to physiological changes. Here we present a microfluidic aqueous two‐phase system to generate microcapsules that can release drugs on demand as triggered by focused ultrasound (FUS). The bi...
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024
|
| Online Access: | https://hdl.handle.net/1721.1/154913 |
| _version_ | 1824458261477195776 |
|---|---|
| author | Field, Rachel D Jakus, Margaret A Chen, Xiaoyu Human, Kelia Zhao, Xuanhe Chitnis, Parag V Sia, Samuel K |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Field, Rachel D Jakus, Margaret A Chen, Xiaoyu Human, Kelia Zhao, Xuanhe Chitnis, Parag V Sia, Samuel K |
| author_sort | Field, Rachel D |
| collection | MIT |
| description | Traditional implanted drug delivery systems cannot easily change their release profile in real time to respond to physiological changes. Here we present a microfluidic aqueous two‐phase system to generate microcapsules that can release drugs on demand as triggered by focused ultrasound (FUS). The biphasic microcapsules are made of hydrogels with an outer phase of mixed molecular weight (MW) poly(ethylene glycol) diacrylate that mitigates premature payload release and an inner phase of high MW dextran with payload that breaks down in response to FUS. Compound release from microcapsules could be triggered as desired; 0.4 μg of payload was released across 16 on‐demand steps over days. We detected broadband acoustic signals amidst low heating, suggesting inertial cavitation as a key mechanism for payload release. Overall, FUS‐responsive microcapsules are a biocompatible and wirelessly triggerable structure for on‐demand drug delivery over days to weeks. |
| first_indexed | 2024-09-23T13:52:13Z |
| format | Article |
| id | mit-1721.1/154913 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:23:05Z |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1549132025-01-07T04:37:19Z Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release Field, Rachel D Jakus, Margaret A Chen, Xiaoyu Human, Kelia Zhao, Xuanhe Chitnis, Parag V Sia, Samuel K Massachusetts Institute of Technology. Department of Mechanical Engineering Traditional implanted drug delivery systems cannot easily change their release profile in real time to respond to physiological changes. Here we present a microfluidic aqueous two‐phase system to generate microcapsules that can release drugs on demand as triggered by focused ultrasound (FUS). The biphasic microcapsules are made of hydrogels with an outer phase of mixed molecular weight (MW) poly(ethylene glycol) diacrylate that mitigates premature payload release and an inner phase of high MW dextran with payload that breaks down in response to FUS. Compound release from microcapsules could be triggered as desired; 0.4 μg of payload was released across 16 on‐demand steps over days. We detected broadband acoustic signals amidst low heating, suggesting inertial cavitation as a key mechanism for payload release. Overall, FUS‐responsive microcapsules are a biocompatible and wirelessly triggerable structure for on‐demand drug delivery over days to weeks. 2024-05-10T16:13:17Z 2024-05-10T16:13:17Z 2022-05-09 2024-05-10T16:10:53Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/154913 Field, Rachel D, Jakus, Margaret A, Chen, Xiaoyu, Human, Kelia, Zhao, Xuanhe et al. 2022. "Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release." Angewandte Chemie, 134 (20). en 10.1002/ange.202116515 Angewandte Chemie Creative Commons Attribution-Noncommercial-Share Alike https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Field, Rachel D Jakus, Margaret A Chen, Xiaoyu Human, Kelia Zhao, Xuanhe Chitnis, Parag V Sia, Samuel K Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release |
| title | Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release |
| title_full | Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release |
| title_fullStr | Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release |
| title_full_unstemmed | Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release |
| title_short | Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release |
| title_sort | ultrasound responsive aqueous two phase microcapsules for on demand drug release |
| url | https://hdl.handle.net/1721.1/154913 |
| work_keys_str_mv | AT fieldracheld ultrasoundresponsiveaqueoustwophasemicrocapsulesforondemanddrugrelease AT jakusmargareta ultrasoundresponsiveaqueoustwophasemicrocapsulesforondemanddrugrelease AT chenxiaoyu ultrasoundresponsiveaqueoustwophasemicrocapsulesforondemanddrugrelease AT humankelia ultrasoundresponsiveaqueoustwophasemicrocapsulesforondemanddrugrelease AT zhaoxuanhe ultrasoundresponsiveaqueoustwophasemicrocapsulesforondemanddrugrelease AT chitnisparagv ultrasoundresponsiveaqueoustwophasemicrocapsulesforondemanddrugrelease AT siasamuelk ultrasoundresponsiveaqueoustwophasemicrocapsulesforondemanddrugrelease |