First-in-human trial of an ingestible vitals-monitoring pill
Ingestible electronics can transform how patients are diagnosed and treated across many conditions. We developed an ingestible vitals-monitoring pill (VM pill) capable of monitoring vital signs including respiratory rate and heart rate. VM pill performance was evaluated in a swine model of opiate ov...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024
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| Online Access: | https://hdl.handle.net/1721.1/155012 |
| _version_ | 1811080764430745600 |
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| author | Traverso, Giovanni Finomore, Victor Mahoney, James Kupec, Justin Stansbury, Robert Bacher, Daniel Pless, Benjamin Schuetz, Shannon Hayward, Alison Langer, Robert Rezai, Ali |
| author_facet | Traverso, Giovanni Finomore, Victor Mahoney, James Kupec, Justin Stansbury, Robert Bacher, Daniel Pless, Benjamin Schuetz, Shannon Hayward, Alison Langer, Robert Rezai, Ali |
| author_sort | Traverso, Giovanni |
| collection | MIT |
| description | Ingestible electronics can transform how patients are diagnosed and treated across many conditions. We developed an ingestible vitals-monitoring pill (VM pill) capable of monitoring vital signs including respiratory rate and heart rate. VM pill performance was evaluated in a swine model of opiate overdose and in a human trial of patients in a sleep laboratory. Sleep studies involve admission to a facility, placement of multiple skin sensors, and overnight observation. We hypothesized that the VM pill could diagnose clinically significant changes in respiratory status, such as apnea, unobtrusively. The VM pill was evaluated in 10 human subjects with no adverse events. The data streams captured by the VM pill achieved high concordance with standard sleep study metrics. Ingestible vital sign monitors can transform the diagnosis of sleep-related respiratory disorders and can capture life-threatening events such as apnea or opioid overdose. |
| first_indexed | 2024-09-23T11:36:28Z |
| format | Article |
| id | mit-1721.1/155012 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:36:28Z |
| publishDate | 2024 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1550122024-09-19T05:44:44Z First-in-human trial of an ingestible vitals-monitoring pill Traverso, Giovanni Finomore, Victor Mahoney, James Kupec, Justin Stansbury, Robert Bacher, Daniel Pless, Benjamin Schuetz, Shannon Hayward, Alison Langer, Robert Rezai, Ali Ingestible electronics can transform how patients are diagnosed and treated across many conditions. We developed an ingestible vitals-monitoring pill (VM pill) capable of monitoring vital signs including respiratory rate and heart rate. VM pill performance was evaluated in a swine model of opiate overdose and in a human trial of patients in a sleep laboratory. Sleep studies involve admission to a facility, placement of multiple skin sensors, and overnight observation. We hypothesized that the VM pill could diagnose clinically significant changes in respiratory status, such as apnea, unobtrusively. The VM pill was evaluated in 10 human subjects with no adverse events. The data streams captured by the VM pill achieved high concordance with standard sleep study metrics. Ingestible vital sign monitors can transform the diagnosis of sleep-related respiratory disorders and can capture life-threatening events such as apnea or opioid overdose. 2024-05-21T16:41:53Z 2024-05-21T16:41:53Z 2023-11 2024-05-21T16:30:06Z Article http://purl.org/eprint/type/JournalArticle 2666-9986 https://hdl.handle.net/1721.1/155012 Traverso, Giovanni, Finomore, Victor, Mahoney, James, Kupec, Justin, Stansbury, Robert et al. 2023. "First-in-human trial of an ingestible vitals-monitoring pill." Device, 1 (5). en 10.1016/j.device.2023.100125 Device Creative Commons Attribution-NonCommercial-NoDerivs License https://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Traverso, Giovanni Finomore, Victor Mahoney, James Kupec, Justin Stansbury, Robert Bacher, Daniel Pless, Benjamin Schuetz, Shannon Hayward, Alison Langer, Robert Rezai, Ali First-in-human trial of an ingestible vitals-monitoring pill |
| title | First-in-human trial of an ingestible vitals-monitoring pill |
| title_full | First-in-human trial of an ingestible vitals-monitoring pill |
| title_fullStr | First-in-human trial of an ingestible vitals-monitoring pill |
| title_full_unstemmed | First-in-human trial of an ingestible vitals-monitoring pill |
| title_short | First-in-human trial of an ingestible vitals-monitoring pill |
| title_sort | first in human trial of an ingestible vitals monitoring pill |
| url | https://hdl.handle.net/1721.1/155012 |
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