Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery
Patient adherence to chronic therapies can be suboptimal, leading to poor therapeutic outcomes. Dosage forms that enable reduction in dosing frequency stand to improve patient adherence. Variation in gastrointestinal transit time, inter-individual differences in gastrointestinal physiology and diffe...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024
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| Online Access: | https://hdl.handle.net/1721.1/155013 |
| _version_ | 1826191911365378048 |
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| author | Li, Ying Lee, Jung Seung Kirtane, Ameya R. Li, Mengyuan Coffey, Charles William Hess, Kaitlyn Lopes, Aaron Collins, Joy Tamang, Siddartha Ishida, Keiko Hayward, Alison Wainer, Jacob Wentworth, Adam J. Traverso, Giovanni |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Li, Ying Lee, Jung Seung Kirtane, Ameya R. Li, Mengyuan Coffey, Charles William Hess, Kaitlyn Lopes, Aaron Collins, Joy Tamang, Siddartha Ishida, Keiko Hayward, Alison Wainer, Jacob Wentworth, Adam J. Traverso, Giovanni |
| author_sort | Li, Ying |
| collection | MIT |
| description | Patient adherence to chronic therapies can be suboptimal, leading to poor therapeutic outcomes. Dosage forms that enable reduction in dosing frequency stand to improve patient adherence. Variation in gastrointestinal transit time, inter-individual differences in gastrointestinal physiology and differences in physicochemical properties of drugs represent challenges to the development of such systems. To this end, a small intestine-targeted drug delivery system is developed, where prolonged gastrointestinal retention and sustained release are achieved through tissue adhesion of drug pills mediated by an essential intestinal enzyme catalase. Here proof-of-concept pharmacokinetics is demonstrated in the swine model for two drugs, hydrophilic amoxicillin and hydrophobic levodopa. It is anticipated that this system can be applicable for many drugs with a diverse of physicochemical characteristics. |
| first_indexed | 2024-09-23T09:03:13Z |
| format | Article |
| id | mit-1721.1/155013 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:17:37Z |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1550132024-12-23T05:53:25Z Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery Li, Ying Lee, Jung Seung Kirtane, Ameya R. Li, Mengyuan Coffey, Charles William Hess, Kaitlyn Lopes, Aaron Collins, Joy Tamang, Siddartha Ishida, Keiko Hayward, Alison Wainer, Jacob Wentworth, Adam J. Traverso, Giovanni Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Massachusetts Institute of Technology. Department of Mechanical Engineering Patient adherence to chronic therapies can be suboptimal, leading to poor therapeutic outcomes. Dosage forms that enable reduction in dosing frequency stand to improve patient adherence. Variation in gastrointestinal transit time, inter-individual differences in gastrointestinal physiology and differences in physicochemical properties of drugs represent challenges to the development of such systems. To this end, a small intestine-targeted drug delivery system is developed, where prolonged gastrointestinal retention and sustained release are achieved through tissue adhesion of drug pills mediated by an essential intestinal enzyme catalase. Here proof-of-concept pharmacokinetics is demonstrated in the swine model for two drugs, hydrophilic amoxicillin and hydrophobic levodopa. It is anticipated that this system can be applicable for many drugs with a diverse of physicochemical characteristics. 2024-05-21T16:52:35Z 2024-05-21T16:52:35Z 2023-10 2024-05-21T16:48:08Z Article http://purl.org/eprint/type/JournalArticle 2192-2640 2192-2659 https://hdl.handle.net/1721.1/155013 Y. Li, J. S. Lee, A. R. Kirtane, M. Li, C. W. Coffey III, K. Hess, A. Lopes, J. Collins, S. Tamang, K. Ishida, A. Hayward, J. Wainer, A. J. Wentworth, G. Traverso, Enzyme-Triggered Intestine-Specific Targeting Adhesive Platform for Universal Oral Drug Delivery. Adv. Healthcare Mater. 2023, 12, 2301033. en 10.1002/adhm.202370169 Advanced Healthcare Materials Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Li, Ying Lee, Jung Seung Kirtane, Ameya R. Li, Mengyuan Coffey, Charles William Hess, Kaitlyn Lopes, Aaron Collins, Joy Tamang, Siddartha Ishida, Keiko Hayward, Alison Wainer, Jacob Wentworth, Adam J. Traverso, Giovanni Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery |
| title | Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery |
| title_full | Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery |
| title_fullStr | Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery |
| title_full_unstemmed | Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery |
| title_short | Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery |
| title_sort | enzyme triggered intestine specific targeting adhesive platform for universal oral drug delivery |
| url | https://hdl.handle.net/1721.1/155013 |
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