Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors
Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obsta...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024
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| Online Access: | https://hdl.handle.net/1721.1/155040 |
| _version_ | 1811096752531439616 |
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| author | Bi, Jianling Witt, Emily Voltarelli, Vanessa A. Feig, Vivian R. Venkatachalam, Veena Boyce, Hannah McGovern, Megan Gutierrez, Wade R. Rytlewski, Jeffrey D. Bowman, Kate R. Rhodes, Ashley C. Cook, Austin N. Muller, Benjamin N. Smith, Matthew G. Ramos, Alexis Rebecca Panchal, Heena Dodd, Rebecca D. Henry, Michael D. Mailloux, Adam Traverso, Giovanni Otterbein, Leo E. Byrne, James D. |
| author_facet | Bi, Jianling Witt, Emily Voltarelli, Vanessa A. Feig, Vivian R. Venkatachalam, Veena Boyce, Hannah McGovern, Megan Gutierrez, Wade R. Rytlewski, Jeffrey D. Bowman, Kate R. Rhodes, Ashley C. Cook, Austin N. Muller, Benjamin N. Smith, Matthew G. Ramos, Alexis Rebecca Panchal, Heena Dodd, Rebecca D. Henry, Michael D. Mailloux, Adam Traverso, Giovanni Otterbein, Leo E. Byrne, James D. |
| author_sort | Bi, Jianling |
| collection | MIT |
| description | Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas‐entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O<jats:sub>2</jats:sub>)‐GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O<jats:sub>2</jats:sub>‐GeMs is promising as an adjunctive strategy for the treatment of solid tumors. |
| first_indexed | 2024-09-23T16:48:29Z |
| format | Article |
| id | mit-1721.1/155040 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:48:29Z |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1550402024-09-20T04:08:36Z Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors Bi, Jianling Witt, Emily Voltarelli, Vanessa A. Feig, Vivian R. Venkatachalam, Veena Boyce, Hannah McGovern, Megan Gutierrez, Wade R. Rytlewski, Jeffrey D. Bowman, Kate R. Rhodes, Ashley C. Cook, Austin N. Muller, Benjamin N. Smith, Matthew G. Ramos, Alexis Rebecca Panchal, Heena Dodd, Rebecca D. Henry, Michael D. Mailloux, Adam Traverso, Giovanni Otterbein, Leo E. Byrne, James D. Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas‐entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O<jats:sub>2</jats:sub>)‐GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O<jats:sub>2</jats:sub>‐GeMs is promising as an adjunctive strategy for the treatment of solid tumors. 2024-05-22T18:12:03Z 2024-05-22T18:12:03Z 2023-02-02 2024-05-22T14:56:46Z Article http://purl.org/eprint/type/JournalArticle 2198-3844 2198-3844 https://hdl.handle.net/1721.1/155040 J. Bi, E. Witt, V. A. Voltarelli, V. R. Feig, V. Venkatachalam, H. Boyce, M. McGovern, W. R. Gutierrez, J. D. Rytlewski, K. R. Bowman, A. C. Rhodes, A. N. Cook, B. N. Muller, M. G. Smith, A. R. Ramos, H. Panchal, R. D. Dodd, M. D. Henry, A. Mailloux, G. Traverso, L. E. Otterbein, J. D. Byrne, Low-Cost, High-Pressure-Synthesized Oxygen-Entrapping Materials to Improve Treatment of Solid Tumors. Adv. Sci. 2023, 10, 2205995. en 10.1002/advs.202205995 Advanced Science Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Bi, Jianling Witt, Emily Voltarelli, Vanessa A. Feig, Vivian R. Venkatachalam, Veena Boyce, Hannah McGovern, Megan Gutierrez, Wade R. Rytlewski, Jeffrey D. Bowman, Kate R. Rhodes, Ashley C. Cook, Austin N. Muller, Benjamin N. Smith, Matthew G. Ramos, Alexis Rebecca Panchal, Heena Dodd, Rebecca D. Henry, Michael D. Mailloux, Adam Traverso, Giovanni Otterbein, Leo E. Byrne, James D. Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
| title | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
| title_full | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
| title_fullStr | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
| title_full_unstemmed | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
| title_short | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
| title_sort | low cost high pressure synthesized oxygen entrapping materials to improve treatment of solid tumors |
| url | https://hdl.handle.net/1721.1/155040 |
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