Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery
Oral drug administration remains the preferred route for patients and health care providers. Delivery of macromolecules through this route remains challenging because of limitations imposed by the transport across the gastrointestinal epithelium and the dynamic and degradative environment. Here, we...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science
2024
|
| Online Access: | https://hdl.handle.net/1721.1/155046 |
| _version_ | 1826196129093517312 |
|---|---|
| author | Chen, Wei Wainer, Jacob Ryoo, Si Won Qi, Xiaoyue Chang, Rong Li, Jason Lee, Seung Ho Min, Seokkee Wentworth, Adam Collins, Joy E. Tamang, Siddartha Ishida, Keiko Hayward, Alison Langer, Robert Traverso, Giovanni |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Chen, Wei Wainer, Jacob Ryoo, Si Won Qi, Xiaoyue Chang, Rong Li, Jason Lee, Seung Ho Min, Seokkee Wentworth, Adam Collins, Joy E. Tamang, Siddartha Ishida, Keiko Hayward, Alison Langer, Robert Traverso, Giovanni |
| author_sort | Chen, Wei |
| collection | MIT |
| description | Oral drug administration remains the preferred route for patients and health care providers. Delivery of macromolecules through this route remains challenging because of limitations imposed by the transport across the gastrointestinal epithelium and the dynamic and degradative environment. Here, we present the development of a delivery system that combines physical (microneedle) and nonphysical (enhancer) modes of drug delivery enhancement for a macromolecule in a large animal model. Inspired by the thorny-headed intestinal worm, we report a dynamic omnidirectional mucoadhesive microneedle system capable of prolonged gastric mucosa fixation. Moreover, we incorporate sodium N-[8-(2-hydroxybenzoyl) amino] caprylate along with semaglutide and demonstrate enhanced absorption in swine resistant to physical displacement in the gastric cavity. Meanwhile, we developed a targeted capsule system capable of deploying intact microneedle-containing systems. These systems stand to enable the delivery of a range of drugs through the generation and maintenance of a privileged region in the gastrointestinal tract. |
| first_indexed | 2024-09-23T10:21:49Z |
| format | Article |
| id | mit-1721.1/155046 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:19:14Z |
| publishDate | 2024 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | mit-1721.1/1550462024-12-23T05:00:30Z Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery Chen, Wei Wainer, Jacob Ryoo, Si Won Qi, Xiaoyue Chang, Rong Li, Jason Lee, Seung Ho Min, Seokkee Wentworth, Adam Collins, Joy E. Tamang, Siddartha Ishida, Keiko Hayward, Alison Langer, Robert Traverso, Giovanni Massachusetts Institute of Technology. Department of Mechanical Engineering Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Division of Comparative Medicine Massachusetts Institute of Technology. Department of Chemical Engineering Oral drug administration remains the preferred route for patients and health care providers. Delivery of macromolecules through this route remains challenging because of limitations imposed by the transport across the gastrointestinal epithelium and the dynamic and degradative environment. Here, we present the development of a delivery system that combines physical (microneedle) and nonphysical (enhancer) modes of drug delivery enhancement for a macromolecule in a large animal model. Inspired by the thorny-headed intestinal worm, we report a dynamic omnidirectional mucoadhesive microneedle system capable of prolonged gastric mucosa fixation. Moreover, we incorporate sodium N-[8-(2-hydroxybenzoyl) amino] caprylate along with semaglutide and demonstrate enhanced absorption in swine resistant to physical displacement in the gastric cavity. Meanwhile, we developed a targeted capsule system capable of deploying intact microneedle-containing systems. These systems stand to enable the delivery of a range of drugs through the generation and maintenance of a privileged region in the gastrointestinal tract. 2024-05-23T19:24:12Z 2024-05-23T19:24:12Z 2022-01-07 2024-05-23T19:15:21Z Article http://purl.org/eprint/type/JournalArticle 2375-2548 https://hdl.handle.net/1721.1/155046 Wei Chen et al. ,Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery.Sci. Adv.8,eabk1792(2022). en 10.1126/sciadv.abk1792 Science Advances Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf American Association for the Advancement of Science American Association for the Advancement of Science |
| spellingShingle | Chen, Wei Wainer, Jacob Ryoo, Si Won Qi, Xiaoyue Chang, Rong Li, Jason Lee, Seung Ho Min, Seokkee Wentworth, Adam Collins, Joy E. Tamang, Siddartha Ishida, Keiko Hayward, Alison Langer, Robert Traverso, Giovanni Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery |
| title | Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery |
| title_full | Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery |
| title_fullStr | Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery |
| title_full_unstemmed | Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery |
| title_short | Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery |
| title_sort | dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery |
| url | https://hdl.handle.net/1721.1/155046 |
| work_keys_str_mv | AT chenwei dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT wainerjacob dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT ryoosiwon dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT qixiaoyue dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT changrong dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT lijason dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT leeseungho dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT minseokkee dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT wentworthadam dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT collinsjoye dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT tamangsiddartha dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT ishidakeiko dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT haywardalison dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT langerrobert dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery AT traversogiovanni dynamicomnidirectionaladhesivemicroneedlesystemfororalmacromoleculardrugdelivery |