Generation of Rhesus Macaque Embryos with Expanded CAG Trinucleotide Repeats in the Huntingtin Gene

Generation of Rhesus Macaque Embryos with Expanded CAG Trinucleotide Repeats in the Huntingtin Gene

Huntington’s disease (HD) arises from expanded CAG repeats in exon 1 of the <i>Huntingtin</i> (<i>HTT</i>) gene. The resultant misfolded HTT protein accumulates within neuronal cells, negatively impacting their function and survival. Ultimately, HTT accumulation res...

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Bibliographic Details
Main Authors:	Ryu, Junghyun, Statz, John P., Chan, William, Oyama, Kiana, Custer, Maggie, Wienisch, Martin, Chen, Richard, Hanna, Carol B., Hennebold, Jon D.
Format:	Article
Published:	MDPI AG 2024
Online Access:	https://hdl.handle.net/1721.1/155075

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