A Compact Hydraulic Head Auto-Regulating Module (CHARM) for Long-Term Constant Gravity-Driven Flow Microfluidics
Gravity-driven flow is a simple microfluidic flow initiation and maintenance mechanism that requires no external power sources and low expertise to use. However, the driving forces created by hydraulic head differences gradually decrease during operation, resulting in unwanted decreased flow rates i...
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| Eará dahkkit: | |
| Materiálatiipa: | Oahppočájánas |
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Massachusetts Institute of Technology
2024
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| Liŋkkat: | https://hdl.handle.net/1721.1/156321 https://orcid.org/0000-0003-4172-7954 |
| _version_ | 1826217938739265536 |
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| author | Xue, Fan |
| author2 | Voldman, Joel |
| author_facet | Voldman, Joel Xue, Fan |
| author_sort | Xue, Fan |
| collection | MIT |
| description | Gravity-driven flow is a simple microfluidic flow initiation and maintenance mechanism that requires no external power sources and low expertise to use. However, the driving forces created by hydraulic head differences gradually decrease during operation, resulting in unwanted decreased flow rates in many microfluidic applications. The existing methods to maintain a constant flow for gravity-driven mechanisms either require additional bulky control equipment, involve complex fabrication or operation, or introduce interfaces that lack robustness. To solve those problems, a compact hydraulic head auto-regulating module (CHARM) was designed and tested in this thesis. The module was able to maintain the liquid level at the microfluidic inlet port within a small fluctuation range without human intervention for a long operation time. The design’s compactness and its compatibility with the standard 96 well plates enable high-throughput operations, and the chosen material’s bio-compatibility allows the devices’ use on cell culture related applications. |
| first_indexed | 2024-09-23T17:11:26Z |
| format | Thesis |
| id | mit-1721.1/156321 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T17:11:26Z |
| publishDate | 2024 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1563212024-08-22T03:00:51Z A Compact Hydraulic Head Auto-Regulating Module (CHARM) for Long-Term Constant Gravity-Driven Flow Microfluidics Xue, Fan Voldman, Joel Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Gravity-driven flow is a simple microfluidic flow initiation and maintenance mechanism that requires no external power sources and low expertise to use. However, the driving forces created by hydraulic head differences gradually decrease during operation, resulting in unwanted decreased flow rates in many microfluidic applications. The existing methods to maintain a constant flow for gravity-driven mechanisms either require additional bulky control equipment, involve complex fabrication or operation, or introduce interfaces that lack robustness. To solve those problems, a compact hydraulic head auto-regulating module (CHARM) was designed and tested in this thesis. The module was able to maintain the liquid level at the microfluidic inlet port within a small fluctuation range without human intervention for a long operation time. The design’s compactness and its compatibility with the standard 96 well plates enable high-throughput operations, and the chosen material’s bio-compatibility allows the devices’ use on cell culture related applications. S.M. 2024-08-21T18:56:38Z 2024-08-21T18:56:38Z 2024-05 2024-07-10T13:00:03.995Z Thesis https://hdl.handle.net/1721.1/156321 https://orcid.org/0000-0003-4172-7954 In Copyright - Educational Use Permitted Copyright retained by author(s) https://rightsstatements.org/page/InC-EDU/1.0/ application/pdf Massachusetts Institute of Technology |
| spellingShingle | Xue, Fan A Compact Hydraulic Head Auto-Regulating Module (CHARM) for Long-Term Constant Gravity-Driven Flow Microfluidics |
| title | A Compact Hydraulic Head Auto-Regulating Module (CHARM) for Long-Term Constant Gravity-Driven Flow Microfluidics |
| title_full | A Compact Hydraulic Head Auto-Regulating Module (CHARM) for Long-Term Constant Gravity-Driven Flow Microfluidics |
| title_fullStr | A Compact Hydraulic Head Auto-Regulating Module (CHARM) for Long-Term Constant Gravity-Driven Flow Microfluidics |
| title_full_unstemmed | A Compact Hydraulic Head Auto-Regulating Module (CHARM) for Long-Term Constant Gravity-Driven Flow Microfluidics |
| title_short | A Compact Hydraulic Head Auto-Regulating Module (CHARM) for Long-Term Constant Gravity-Driven Flow Microfluidics |
| title_sort | compact hydraulic head auto regulating module charm for long term constant gravity driven flow microfluidics |
| url | https://hdl.handle.net/1721.1/156321 https://orcid.org/0000-0003-4172-7954 |
| work_keys_str_mv | AT xuefan acompacthydraulicheadautoregulatingmodulecharmforlongtermconstantgravitydrivenflowmicrofluidics AT xuefan compacthydraulicheadautoregulatingmodulecharmforlongtermconstantgravitydrivenflowmicrofluidics |