Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing

The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for messenger RNA and CR...

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Bibliographic Details
Main Authors: Li, Bowen, Manan, Rajith Singh, Liang, Shun-Qing, Gordon, Akiva, Jiang, Allen, Varley, Andrew, Gao, Guangping, Langer, Robert, Xue, Wen, Anderson, Daniel
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2024
Online Access:https://hdl.handle.net/1721.1/156898

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