Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy
Self‐regulated insulin delivery that mimics native pancreas function has been a long‐term goal for diabetes therapies. Two approaches towards this goal are glucose‐responsive insulin delivery and islet cell transplantation therapy. Here, biodegradable, partially oxidized alginate carriers for glucos...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024
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| Online Access: | https://hdl.handle.net/1721.1/156900 |
| _version_ | 1811095674862698496 |
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| author | Volpatti, Lisa R Bochenek, Matthew A Facklam, Amanda L Burns, Delaney M MacIsaac, Corina Morgart, Alexander Walters, Benjamin Langer, Robert Anderson, Daniel G |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Volpatti, Lisa R Bochenek, Matthew A Facklam, Amanda L Burns, Delaney M MacIsaac, Corina Morgart, Alexander Walters, Benjamin Langer, Robert Anderson, Daniel G |
| author_sort | Volpatti, Lisa R |
| collection | MIT |
| description | Self‐regulated insulin delivery that mimics native pancreas function has been a long‐term goal for diabetes therapies. Two approaches towards this goal are glucose‐responsive insulin delivery and islet cell transplantation therapy. Here, biodegradable, partially oxidized alginate carriers for glucose‐responsive nanoparticles or islet cells are developed. Material composition and formulation are tuned in each of these contexts to enable glycemic control in diabetic mice. For injectable, glucose‐responsive insulin delivery, 0.5 mm 2.5% oxidized alginate microgels facilitate repeat dosing and consistently provide 10 days of glycemic control. For islet cell transplantation, 1.5 mm capsules comprised of a blend of unoxidized and 2.5% oxidized alginate maintain cell viability and glycemic control over a period of more than 2 months while reducing the volume of nondegradable material implanted. These data show the potential of these biodegradable carriers for controlled drug and cell delivery for the treatment of diabetes with limited material accumulation in the event of multiple doses. |
| first_indexed | 2024-09-23T16:24:02Z |
| format | Article |
| id | mit-1721.1/156900 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:24:02Z |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1569002024-09-19T03:03:07Z Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy Volpatti, Lisa R Bochenek, Matthew A Facklam, Amanda L Burns, Delaney M MacIsaac, Corina Morgart, Alexander Walters, Benjamin Langer, Robert Anderson, Daniel G Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Biological Engineering Harvard-MIT Program in Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Self‐regulated insulin delivery that mimics native pancreas function has been a long‐term goal for diabetes therapies. Two approaches towards this goal are glucose‐responsive insulin delivery and islet cell transplantation therapy. Here, biodegradable, partially oxidized alginate carriers for glucose‐responsive nanoparticles or islet cells are developed. Material composition and formulation are tuned in each of these contexts to enable glycemic control in diabetic mice. For injectable, glucose‐responsive insulin delivery, 0.5 mm 2.5% oxidized alginate microgels facilitate repeat dosing and consistently provide 10 days of glycemic control. For islet cell transplantation, 1.5 mm capsules comprised of a blend of unoxidized and 2.5% oxidized alginate maintain cell viability and glycemic control over a period of more than 2 months while reducing the volume of nondegradable material implanted. These data show the potential of these biodegradable carriers for controlled drug and cell delivery for the treatment of diabetes with limited material accumulation in the event of multiple doses. 2024-09-18T21:05:49Z 2024-09-18T21:05:49Z 2023-01 2024-09-18T20:58:34Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/156900 Volpatti, Lisa R, Bochenek, Matthew A, Facklam, Amanda L, Burns, Delaney M, MacIsaac, Corina et al. 2023. "Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy." Advanced Healthcare Materials, 12 (2). en 10.1002/adhm.202201822 Advanced Healthcare Materials Creative Commons Attribution-Noncommercial-ShareAlike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PubMed Central |
| spellingShingle | Volpatti, Lisa R Bochenek, Matthew A Facklam, Amanda L Burns, Delaney M MacIsaac, Corina Morgart, Alexander Walters, Benjamin Langer, Robert Anderson, Daniel G Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy |
| title | Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy |
| title_full | Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy |
| title_fullStr | Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy |
| title_full_unstemmed | Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy |
| title_short | Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy |
| title_sort | partially oxidized alginate as a biodegradable carrier for glucose responsive insulin delivery and islet cell replacement therapy |
| url | https://hdl.handle.net/1721.1/156900 |
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