Charge shielding effects of PEG bound to NH2-terminated PAMAM dendrimers – an experimental approach

Charge shielding effects of PEG bound to NH2-terminated PAMAM dendrimers – an experimental approach

Cationic poly(amido amine) (PAMAM) dendrimers exhibit great potential for use in drug delivery, but their high charge density leads to an inherent cytotoxicity. To increase biocompatibility, many studies have attached poly(ethylene glycol) (PEG) chains to the dendrimer surface. It is unclear how the...

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Detalles Bibliográficos
Autores principales: Johnston, Brandon M, Grodzinsky, Alan J, Hammond, Paula T
Otros Autores: Massachusetts Institute of Technology. Department of Chemical Engineering
Formato: Artículo
Lenguaje:English
Publicado: Royal Society of Chemistry 2024
Acceso en línea:https://hdl.handle.net/1721.1/156916

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