Imidazolium-based ionic liquids support biosimilar flavin electron transfer
Understanding electron transport with electroactive microbes is key to engineering effective and scalable bio-electrochemical technologies. Much of this electron transfer occurs through small-molecule flavin mediators that perform one-electron transfers in abiotic systems but concerted two-electron...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2024
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| Online Access: | https://hdl.handle.net/1721.1/157468 |
| _version_ | 1824458047608586240 |
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| author | Anderson, Grace I Agee, Alec A Furst, Ariel L |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Anderson, Grace I Agee, Alec A Furst, Ariel L |
| author_sort | Anderson, Grace I |
| collection | MIT |
| description | Understanding electron transport with electroactive microbes is key to engineering effective and scalable bio-electrochemical technologies. Much of this electron transfer occurs through small-molecule flavin mediators that perform one-electron transfers in abiotic systems but concerted two-electron transfer in biological systems, rendering abiotic systems less efficient. To boost efficiency, the principles guiding flavin electron transfer must be elucidated, necessitating a tunable system. Ionic liquids (ILs) offer such a platform due to their chemical diversity. In particular, imidazolium-containing ILs that resemble the amino acid histidine are bio-similar electrolytes that enable the study of flavin electron transfer. Using the model IL 1-ethyl-3-methylimidazolium ([Emim][BF4]), we observe concerted two-electron transfer between flavin mononucleotide and an unmodified glassy carbon electrode surface, while a one-electron transfer occurs in standard inorganic electrolytes. This work demonstrates the power of ILs to enable the mechanistic study of biological electron transfer, providing critical guidelines for improving electrochemical technologies based on these biological properties. |
| first_indexed | 2025-02-19T04:19:41Z |
| format | Article |
| id | mit-1721.1/157468 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:19:41Z |
| publishDate | 2024 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | mit-1721.1/1574682024-12-21T06:00:26Z Imidazolium-based ionic liquids support biosimilar flavin electron transfer Anderson, Grace I Agee, Alec A Furst, Ariel L Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Center for Environmental Health Sciences Understanding electron transport with electroactive microbes is key to engineering effective and scalable bio-electrochemical technologies. Much of this electron transfer occurs through small-molecule flavin mediators that perform one-electron transfers in abiotic systems but concerted two-electron transfer in biological systems, rendering abiotic systems less efficient. To boost efficiency, the principles guiding flavin electron transfer must be elucidated, necessitating a tunable system. Ionic liquids (ILs) offer such a platform due to their chemical diversity. In particular, imidazolium-containing ILs that resemble the amino acid histidine are bio-similar electrolytes that enable the study of flavin electron transfer. Using the model IL 1-ethyl-3-methylimidazolium ([Emim][BF4]), we observe concerted two-electron transfer between flavin mononucleotide and an unmodified glassy carbon electrode surface, while a one-electron transfer occurs in standard inorganic electrolytes. This work demonstrates the power of ILs to enable the mechanistic study of biological electron transfer, providing critical guidelines for improving electrochemical technologies based on these biological properties. 2024-11-04T20:07:59Z 2024-11-04T20:07:59Z 2024-08-27 2024-11-04T19:57:20Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/157468 Mater. Adv., 2024,5, 6813-6819 en 10.1039/d4ma00558a Materials Advances Creative Commons Attribution http://creativecommons.org/licenses/by-nc/4.0/ application/pdf Royal Society of Chemistry Royal Society of Chemistry |
| spellingShingle | Anderson, Grace I Agee, Alec A Furst, Ariel L Imidazolium-based ionic liquids support biosimilar flavin electron transfer |
| title | Imidazolium-based ionic liquids support biosimilar flavin electron transfer |
| title_full | Imidazolium-based ionic liquids support biosimilar flavin electron transfer |
| title_fullStr | Imidazolium-based ionic liquids support biosimilar flavin electron transfer |
| title_full_unstemmed | Imidazolium-based ionic liquids support biosimilar flavin electron transfer |
| title_short | Imidazolium-based ionic liquids support biosimilar flavin electron transfer |
| title_sort | imidazolium based ionic liquids support biosimilar flavin electron transfer |
| url | https://hdl.handle.net/1721.1/157468 |
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