Total Synthesis of Verticillin A and Application of Diazene-Directed Fragment Assembly to the Synthesis of Heterodimeric Epidithiodiketopiperazine Derivatives
I. Total Synthesis of (+)-Verticillin A We report the first total synthesis of (+)-verticillin A, completed in 16 steps. Our initial strategy of late-stage sulfidation on a dimeric substrate produced an undesired diastereomer of ETP. We were able to access an ETP with the desired diastereoselectivit...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/157574 |