Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing
Biological systems play a key role in many advanced manufacturing processes, of which many have interesting nonlinear dynamics. We investigate a continuous yeast cell manufacturing process that produces sustained oscillations in outputs under nominal conditions. Using a population balance model to p...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2024
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| Online Access: | https://hdl.handle.net/1721.1/157693 |
| _version_ | 1824458111570673664 |
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| author | Ganko, Krystian Berliner, Marc D Rhyu, Jinwook Wu, Liang Braatz, Richard D Leyffer, Sven |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Ganko, Krystian Berliner, Marc D Rhyu, Jinwook Wu, Liang Braatz, Richard D Leyffer, Sven |
| author_sort | Ganko, Krystian |
| collection | MIT |
| description | Biological systems play a key role in many advanced manufacturing processes, of which many have interesting nonlinear dynamics. We investigate a continuous yeast cell manufacturing process that produces sustained oscillations in outputs under nominal conditions. Using a population balance model to perform dynamic optimization with multiple objectives and observability constraints, we quantify tradeoffs on the Pareto surface for varying the extent of process oscillations that the decision-maker deems tolerable (or desirable). Numerical optimal control design for oscillatory distributed parameter systems is discussed within the context of both dynamic optimization and on-line nonlinear model predictive control strategies. |
| first_indexed | 2025-02-19T04:20:42Z |
| format | Article |
| id | mit-1721.1/157693 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:20:42Z |
| publishDate | 2024 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1576932025-01-12T04:58:04Z Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing Ganko, Krystian Berliner, Marc D Rhyu, Jinwook Wu, Liang Braatz, Richard D Leyffer, Sven Massachusetts Institute of Technology. Department of Chemical Engineering Biological systems play a key role in many advanced manufacturing processes, of which many have interesting nonlinear dynamics. We investigate a continuous yeast cell manufacturing process that produces sustained oscillations in outputs under nominal conditions. Using a population balance model to perform dynamic optimization with multiple objectives and observability constraints, we quantify tradeoffs on the Pareto surface for varying the extent of process oscillations that the decision-maker deems tolerable (or desirable). Numerical optimal control design for oscillatory distributed parameter systems is discussed within the context of both dynamic optimization and on-line nonlinear model predictive control strategies. 2024-11-27T20:04:39Z 2024-11-27T20:04:39Z 2024 2024-11-27T19:57:44Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/157693 Ganko, Krystian, Berliner, Marc D, Rhyu, Jinwook, Wu, Liang, Braatz, Richard D et al. 2024. "Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing." IFAC-PapersOnLine, 58 (14). en 10.1016/j.ifacol.2024.08.445 IFAC-PapersOnLine Creative Commons Attribution-NonCommercial-NoDerivs https://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Ganko, Krystian Berliner, Marc D Rhyu, Jinwook Wu, Liang Braatz, Richard D Leyffer, Sven Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing |
| title | Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing |
| title_full | Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing |
| title_fullStr | Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing |
| title_full_unstemmed | Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing |
| title_short | Population Balance Model-based Dynamic Multiobjective Optimization of Yeast Cell Manufacturing |
| title_sort | population balance model based dynamic multiobjective optimization of yeast cell manufacturing |
| url | https://hdl.handle.net/1721.1/157693 |
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