How J-chain ensures the assembly of immunoglobulin IgM pentamers

How J-chain ensures the assembly of immunoglobulin IgM pentamers

Polymeric IgM immunoglobulins have high avidity for antigen and complement, and dominate primary antibody responses. They are produced either as assemblies of six µ2L2 subunits (i.e., hexamers), or as pentamers of two µ2L2 subunits and an additional protein termed J-chain (JC), which allows transcyt...

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Bibliographic Details
Main Authors: Giannone, Chiara, Mess, Xenia, He, Ruiming, Chelazzi, Maria R., Mayer, Annika, Bakunts, Anush, Nguyen, Tuan, Bushman, Yevheniia, Orsi, Andrea, Gansen, Benedikt, Degano, Massimo, Buchner, Johannes, Sitia, Roberto
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Nature Publishing Group UK 2024
Online Access:https://hdl.handle.net/1721.1/157840

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