Multiple testing for signal-agnostic searches for new physics with machine learning

In this work, we address the question of how to enhance signal-agnostic searches by leveraging multiple testing strategies. Specifically, we consider hypothesis tests relying on machine learning, where model selection can introduce a bias towards specific families of new physics signals. Focusing on...

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Main Authors: Grosso, Gaia, Letizia, Marco
Other Authors: Massachusetts Institute of Technology. Laboratory for Nuclear Science
Format: Article
Language:English
Published: Springer Berlin Heidelberg 2025
Online Access:https://hdl.handle.net/1721.1/157946
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author Grosso, Gaia
Letizia, Marco
author2 Massachusetts Institute of Technology. Laboratory for Nuclear Science
author_facet Massachusetts Institute of Technology. Laboratory for Nuclear Science
Grosso, Gaia
Letizia, Marco
author_sort Grosso, Gaia
collection MIT
description In this work, we address the question of how to enhance signal-agnostic searches by leveraging multiple testing strategies. Specifically, we consider hypothesis tests relying on machine learning, where model selection can introduce a bias towards specific families of new physics signals. Focusing on the New Physics Learning Machine, a methodology to perform a signal-agnostic likelihood-ratio test, we explore a number of approaches to multiple testing, such as combining p-values and aggregating test statistics. Our findings show that it is beneficial to combine different tests, characterised by distinct choices of hyperparameters, and that performances comparable to the best available test are generally achieved, while also providing a more uniform response to various types of anomalies. This study proposes a methodology that is valid beyond machine learning approaches and could in principle be applied to a larger class model-agnostic analyses based on hypothesis testing.
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spelling mit-1721.1/1579462025-01-07T03:54:06Z Multiple testing for signal-agnostic searches for new physics with machine learning Grosso, Gaia Letizia, Marco Massachusetts Institute of Technology. Laboratory for Nuclear Science In this work, we address the question of how to enhance signal-agnostic searches by leveraging multiple testing strategies. Specifically, we consider hypothesis tests relying on machine learning, where model selection can introduce a bias towards specific families of new physics signals. Focusing on the New Physics Learning Machine, a methodology to perform a signal-agnostic likelihood-ratio test, we explore a number of approaches to multiple testing, such as combining p-values and aggregating test statistics. Our findings show that it is beneficial to combine different tests, characterised by distinct choices of hyperparameters, and that performances comparable to the best available test are generally achieved, while also providing a more uniform response to various types of anomalies. This study proposes a methodology that is valid beyond machine learning approaches and could in principle be applied to a larger class model-agnostic analyses based on hypothesis testing. 2025-01-06T18:37:58Z 2025-01-06T18:37:58Z 2025-01-04 2025-01-05T04:11:59Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/157946 Grosso, G., Letizia, M. Multiple testing for signal-agnostic searches for new physics with machine learning. Eur. Phys. J. C 85, 4 (2025). PUBLISHER_CC en https://doi.org/10.1140/epjc/s10052-024-13722-5 The European Physical Journal C Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ The Author(s) application/pdf Springer Berlin Heidelberg Springer Berlin Heidelberg
spellingShingle Grosso, Gaia
Letizia, Marco
Multiple testing for signal-agnostic searches for new physics with machine learning
title Multiple testing for signal-agnostic searches for new physics with machine learning
title_full Multiple testing for signal-agnostic searches for new physics with machine learning
title_fullStr Multiple testing for signal-agnostic searches for new physics with machine learning
title_full_unstemmed Multiple testing for signal-agnostic searches for new physics with machine learning
title_short Multiple testing for signal-agnostic searches for new physics with machine learning
title_sort multiple testing for signal agnostic searches for new physics with machine learning
url https://hdl.handle.net/1721.1/157946
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