An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation
Precise neurostimulation can revolutionize therapies for neurological disorders. Electrode-based stimulation devices face challenges in achieving precise and consistent targeting due to the immune response and the limited penetration of electrical fields. Ultrasound can aid in energy propagation, bu...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2025
|
| Online Access: | https://hdl.handle.net/1721.1/158148 |
| _version_ | 1824458480388407296 |
|---|---|
| author | Hou, Jason F Nayeem, Md Osman Goni Caplan, Kian A Ruesch, Evan A Caban-Murillo, Albit Criado-Hidalgo, Ernesto Ornellas, Sarah B Williams, Brandon Pearce, Ayeilla A Dagdeviren, Huseyin E Surets, Michelle White, John A Shapiro, Mikhail G Wang, Fan Ramirez, Steve Dagdeviren, Canan |
| author2 | Massachusetts Institute of Technology. Media Laboratory |
| author_facet | Massachusetts Institute of Technology. Media Laboratory Hou, Jason F Nayeem, Md Osman Goni Caplan, Kian A Ruesch, Evan A Caban-Murillo, Albit Criado-Hidalgo, Ernesto Ornellas, Sarah B Williams, Brandon Pearce, Ayeilla A Dagdeviren, Huseyin E Surets, Michelle White, John A Shapiro, Mikhail G Wang, Fan Ramirez, Steve Dagdeviren, Canan |
| author_sort | Hou, Jason F |
| collection | MIT |
| description | Precise neurostimulation can revolutionize therapies for neurological disorders. Electrode-based stimulation devices face challenges in achieving precise and consistent targeting due to the immune response and the limited penetration of electrical fields. Ultrasound can aid in energy propagation, but transcranial ultrasound stimulation in the deep brain has limited spatial resolution caused by bone and tissue scattering. Here, we report an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal pressure of 100 kPa to modulate the activity of neurons. ImPULS is a fully-encapsulated, flexible piezoelectric micromachined ultrasound transducer that incorporates a biocompatible piezoceramic, potassium sodium niobate [(K,Na)NbO3]. The absence of electrochemically active elements poses a new strategy for achieving long-term stability. We demonstrated that ImPULS can i) excite neurons in a mouse hippocampal slice ex vivo, ii) activate cells in the hippocampus of an anesthetized mouse to induce expression of activity-dependent gene c-Fos, and iii) stimulate dopaminergic neurons in the substantia nigra pars compacta to elicit time-locked modulation of nigrostriatal dopamine release. This work introduces a non-genetic ultrasound platform for spatially-localized neural stimulation and exploration of basic functions in the deep brain. |
| first_indexed | 2025-02-19T04:26:34Z |
| format | Article |
| id | mit-1721.1/158148 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:26:34Z |
| publishDate | 2025 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1581482025-01-31T19:51:16Z An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation Hou, Jason F Nayeem, Md Osman Goni Caplan, Kian A Ruesch, Evan A Caban-Murillo, Albit Criado-Hidalgo, Ernesto Ornellas, Sarah B Williams, Brandon Pearce, Ayeilla A Dagdeviren, Huseyin E Surets, Michelle White, John A Shapiro, Mikhail G Wang, Fan Ramirez, Steve Dagdeviren, Canan Massachusetts Institute of Technology. Media Laboratory Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Precise neurostimulation can revolutionize therapies for neurological disorders. Electrode-based stimulation devices face challenges in achieving precise and consistent targeting due to the immune response and the limited penetration of electrical fields. Ultrasound can aid in energy propagation, but transcranial ultrasound stimulation in the deep brain has limited spatial resolution caused by bone and tissue scattering. Here, we report an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal pressure of 100 kPa to modulate the activity of neurons. ImPULS is a fully-encapsulated, flexible piezoelectric micromachined ultrasound transducer that incorporates a biocompatible piezoceramic, potassium sodium niobate [(K,Na)NbO3]. The absence of electrochemically active elements poses a new strategy for achieving long-term stability. We demonstrated that ImPULS can i) excite neurons in a mouse hippocampal slice ex vivo, ii) activate cells in the hippocampus of an anesthetized mouse to induce expression of activity-dependent gene c-Fos, and iii) stimulate dopaminergic neurons in the substantia nigra pars compacta to elicit time-locked modulation of nigrostriatal dopamine release. This work introduces a non-genetic ultrasound platform for spatially-localized neural stimulation and exploration of basic functions in the deep brain. 2025-01-31T19:51:14Z 2025-01-31T19:51:14Z 2024 2025-01-31T19:39:19Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/158148 Hou, J.F., Nayeem, M.O.G., Caplan, K.A. et al. An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation. Nat Commun 15, 4601 (2024). en 10.1038/s41467-024-48748-6 Nature Communications Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Springer Science and Business Media LLC |
| spellingShingle | Hou, Jason F Nayeem, Md Osman Goni Caplan, Kian A Ruesch, Evan A Caban-Murillo, Albit Criado-Hidalgo, Ernesto Ornellas, Sarah B Williams, Brandon Pearce, Ayeilla A Dagdeviren, Huseyin E Surets, Michelle White, John A Shapiro, Mikhail G Wang, Fan Ramirez, Steve Dagdeviren, Canan An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation |
| title | An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation |
| title_full | An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation |
| title_fullStr | An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation |
| title_full_unstemmed | An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation |
| title_short | An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation |
| title_sort | implantable piezoelectric ultrasound stimulator impuls for deep brain activation |
| url | https://hdl.handle.net/1721.1/158148 |
| work_keys_str_mv | AT houjasonf animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT nayeemmdosmangoni animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT caplankiana animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT rueschevana animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT cabanmurilloalbit animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT criadohidalgoernesto animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT ornellassarahb animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT williamsbrandon animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT pearceayeillaa animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT dagdevirenhuseyine animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT suretsmichelle animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT whitejohna animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT shapiromikhailg animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT wangfan animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT ramirezsteve animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT dagdevirencanan animplantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT houjasonf implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT nayeemmdosmangoni implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT caplankiana implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT rueschevana implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT cabanmurilloalbit implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT criadohidalgoernesto implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT ornellassarahb implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT williamsbrandon implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT pearceayeillaa implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT dagdevirenhuseyine implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT suretsmichelle implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT whitejohna implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT shapiromikhailg implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT wangfan implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT ramirezsteve implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation AT dagdevirencanan implantablepiezoelectricultrasoundstimulatorimpulsfordeepbrainactivation |