| Summary: | The past decade has seen a number of impressive developments in predictive chemistry and reaction informatics driven by machine learning applications to computer-aided synthesis planning. While many of these developments have been made even with relatively small, bespoke data sets, in order to advance the role of AI in the field at scale, there must be significant improvements in the reporting of reaction data. Currently, the majority of publicly available data is reported in an unstructured format and heavily imbalanced toward high-yielding reactions, which influences the types of models that can be successfully trained. In this Perspective, we analyze several data curation and sharing initiatives that have seen success in chemistry and molecular biology. We discuss several factors that have contributed to their success and how we can take lessons from these case studies and apply them to reaction data. Finally, we spotlight the Open Reaction Database and summarize key actions the community can take toward making reaction data more findable, accessible, interoperable, and reusable (FAIR), including the use of mandates from funding agencies and publishers.
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