Expanding the landscape of antibody discovery
Library:library screening technologies hold substantial promise for paired antibody:antigen discovery, but challenges have persisted. In this issue of Cell Reports Methods, Wagner et al. introduce a method that combines antibody-ribosome-mRNA complexes, antigen cell surface display, and single-cell...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2025
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| Online Access: | https://hdl.handle.net/1721.1/158238 |
| _version_ | 1824457869521584128 |
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| author | Johnson, Shelbe DeKosky, Brandon J |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Johnson, Shelbe DeKosky, Brandon J |
| author_sort | Johnson, Shelbe |
| collection | MIT |
| description | Library:library screening technologies hold substantial promise for paired antibody:antigen discovery, but challenges have persisted. In this issue of Cell Reports Methods, Wagner et al. introduce a method that combines antibody-ribosome-mRNA complexes, antigen cell surface display, and single-cell RNA sequencing to successfully screen diverse antibody gene libraries against a library of viral receptor proteins. |
| first_indexed | 2025-02-19T04:16:51Z |
| format | Article |
| id | mit-1721.1/158238 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2025-02-19T04:16:51Z |
| publishDate | 2025 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1582382025-02-18T23:12:58Z Expanding the landscape of antibody discovery Johnson, Shelbe DeKosky, Brandon J Massachusetts Institute of Technology. Department of Chemical Engineering Ragon Institute of MGH, MIT and Harvard Koch Institute for Integrative Cancer Research at MIT Library:library screening technologies hold substantial promise for paired antibody:antigen discovery, but challenges have persisted. In this issue of Cell Reports Methods, Wagner et al. introduce a method that combines antibody-ribosome-mRNA complexes, antigen cell surface display, and single-cell RNA sequencing to successfully screen diverse antibody gene libraries against a library of viral receptor proteins. 2025-02-18T23:12:57Z 2025-02-18T23:12:57Z 2024-12 2025-02-18T22:33:10Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/158238 Johnson, Shelbe and DeKosky, Brandon J. 2024. "Expanding the landscape of antibody discovery." Cell Reports Methods, 4 (12). en 10.1016/j.crmeth.2024.100936 Cell Reports Methods Creative Commons Attribution-NonCommercial-NoDerivatives https://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier BV |
| spellingShingle | Johnson, Shelbe DeKosky, Brandon J Expanding the landscape of antibody discovery |
| title | Expanding the landscape of antibody discovery |
| title_full | Expanding the landscape of antibody discovery |
| title_fullStr | Expanding the landscape of antibody discovery |
| title_full_unstemmed | Expanding the landscape of antibody discovery |
| title_short | Expanding the landscape of antibody discovery |
| title_sort | expanding the landscape of antibody discovery |
| url | https://hdl.handle.net/1721.1/158238 |
| work_keys_str_mv | AT johnsonshelbe expandingthelandscapeofantibodydiscovery AT dekoskybrandonj expandingthelandscapeofantibodydiscovery |