Cell activation-based screening of natively paired human T cell receptor repertoires

Cell activation-based screening of natively paired human T cell receptor repertoires

Adoptive immune therapies based on the transfer of antigen-specific T cells have been used successfully to treat various cancers and viral infections, but improved techniques are needed to identify optimally protective human T cell receptors (TCRs). Here we present a high-throughput approach to the...

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Bibliographic Details
Main Authors: Fahad, Ahmed S, Chung, Cheng Yu, López Acevedo, Sheila N, Boyle, Nicoleen, Madan, Bharat, Gutiérrez-González, Matías F, Matus-Nicodemos, Rodrigo, Laflin, Amy D, Ladi, Rukmini R, Zhou, John, Wolfe, Jacy, Llewellyn-Lacey, Sian, Koup, Richard A, Douek, Daniel C, Balfour, Henry H, Price, David A, DeKosky, Brandon J
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2025
Online Access:https://hdl.handle.net/1721.1/158239

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