Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare
Bioadhesives—materials capable of adhering to biological tissues—hold significant promise as transformative tools in healthcare, offering the ability to repair tissues with ease and minimal damage. These materials present numerous opportunities in surgery and human-machine interfaces, creating a bro...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2025
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| Online Access: | https://hdl.handle.net/1721.1/158323 |
| _version_ | 1826205606604701696 |
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| author | Wu, Sarah J. |
| author2 | Zhao, Xuanhe |
| author_facet | Zhao, Xuanhe Wu, Sarah J. |
| author_sort | Wu, Sarah J. |
| collection | MIT |
| description | Bioadhesives—materials capable of adhering to biological tissues—hold significant promise as transformative tools in healthcare, offering the ability to repair tissues with ease and minimal damage. These materials present numerous opportunities in surgery and human-machine interfaces, creating a broad landscape of applications that has captivated clinical and scientific interest alike. Still, there remain open challenges surrounding their reliability, biocompatibility, usability, and versatility. These include weak adhesion with wet tissues, foreign body response, cumbersome application processes, and limited customizability. This dissertation presents a multiscale framework for addressing these obstacles, encompassing design strategies on the molecular, polymer network architecture, macroscale device, and application process levels. The implementation of this framework is demonstrated through the development of two pioneering bioadhesive platforms: (1) a multifunctional patch for minimally invasive surgery, and (2) a 3D printable bioadhesive for fabricating tunable, application-specific devices. Together, these platforms expand the design space for creating robust and versatile tissue repair solutions and biomedical devices. |
| first_indexed | 2025-03-10T11:16:23Z |
| format | Thesis |
| id | mit-1721.1/158323 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2025-03-10T11:16:23Z |
| publishDate | 2025 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1583232025-03-05T15:27:44Z Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare Wu, Sarah J. Zhao, Xuanhe Massachusetts Institute of Technology. Department of Mechanical Engineering Bioadhesives—materials capable of adhering to biological tissues—hold significant promise as transformative tools in healthcare, offering the ability to repair tissues with ease and minimal damage. These materials present numerous opportunities in surgery and human-machine interfaces, creating a broad landscape of applications that has captivated clinical and scientific interest alike. Still, there remain open challenges surrounding their reliability, biocompatibility, usability, and versatility. These include weak adhesion with wet tissues, foreign body response, cumbersome application processes, and limited customizability. This dissertation presents a multiscale framework for addressing these obstacles, encompassing design strategies on the molecular, polymer network architecture, macroscale device, and application process levels. The implementation of this framework is demonstrated through the development of two pioneering bioadhesive platforms: (1) a multifunctional patch for minimally invasive surgery, and (2) a 3D printable bioadhesive for fabricating tunable, application-specific devices. Together, these platforms expand the design space for creating robust and versatile tissue repair solutions and biomedical devices. Ph.D. 2025-03-05T15:27:41Z 2025-03-05T15:27:41Z 2024-09 2025-03-03T16:18:29.224Z Thesis https://hdl.handle.net/1721.1/158323 Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) Copyright retained by author(s) https://creativecommons.org/licenses/by-sa/4.0/ application/pdf Massachusetts Institute of Technology |
| spellingShingle | Wu, Sarah J. Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare |
| title | Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare |
| title_full | Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare |
| title_fullStr | Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare |
| title_full_unstemmed | Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare |
| title_short | Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare |
| title_sort | multiscale design of bioadhesive platforms for next generation applications in surgery and healthcare |
| url | https://hdl.handle.net/1721.1/158323 |
| work_keys_str_mv | AT wusarahj multiscaledesignofbioadhesiveplatformsfornextgenerationapplicationsinsurgeryandhealthcare |