Transcutaneous measurement of glucose using Raman spectroscopy
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.
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| Format: | Thesis |
| Language: | en_US |
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Massachusetts Institute of Technology
2005
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| Online Access: | http://hdl.handle.net/1721.1/27121 |
| _version_ | 1811085096111833088 |
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| author | Oh, Jeankun, 1968- |
| author2 | Michael S. Feld. |
| author_facet | Michael S. Feld. Oh, Jeankun, 1968- |
| author_sort | Oh, Jeankun, 1968- |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004. |
| first_indexed | 2024-09-23T13:02:50Z |
| format | Thesis |
| id | mit-1721.1/27121 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:02:50Z |
| publishDate | 2005 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/271212019-04-12T11:57:30Z Transcutaneous measurement of glucose using Raman spectroscopy Oh, Jeankun, 1968- Michael S. Feld. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004. Includes bibliographical references (p. 86-88). Transcutaneous glucose measurement would provide the ability to obtain frequent measurements without the pain and risk of infection associated with obtaining a blood sample and eliminates the need for reagents. Because of these potential benefits, a large effort is being made within the academic and industrial research communities to develop alternative rapid and easily manageable analysis methods, including transcutaneous methods. Several optical techniques have been proposed and investigated widely to replace the traditional method. Transcutaneous measurement would be of particular benefit to the millions of people with diabetes who should monitor glucose levels multiple times per day and today depend on the finger pricking devices. We have used the advantages provided by NIR Raman spectroscopy, i.e. sharp and distinct spectral features combined with a large probe volume, in order to simultaneously quantify multiple analytes (glucose, urea, cholesterol, triglycerides, total protein, albumin, hemoglobin, hematocrit (hct)) in serum and whole blood samples. Based on the successful measurements, we have moved toward transcutaneous measurements of glucose from 16 healthy human subjects as the first target of blood analytes. RMSEP of 13.17 mg/dL and r² values of 0.79 show promise that the Raman spectroscopy can be developed to achieve clinical accuracy requirements. Furthermore, the fact that glucose features could be recognized in the calibration spectra from measurements of volunteers whose glucose levels changed in a relatively large range, provides evidence that the calibration is based upon glucose. by Jeankun Oh. S.M. 2005-09-06T21:50:54Z 2005-09-06T21:50:54Z 2004 2004 Thesis http://hdl.handle.net/1721.1/27121 56842691 en_US M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 88 p. 4673907 bytes 4683635 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Oh, Jeankun, 1968- Transcutaneous measurement of glucose using Raman spectroscopy |
| title | Transcutaneous measurement of glucose using Raman spectroscopy |
| title_full | Transcutaneous measurement of glucose using Raman spectroscopy |
| title_fullStr | Transcutaneous measurement of glucose using Raman spectroscopy |
| title_full_unstemmed | Transcutaneous measurement of glucose using Raman spectroscopy |
| title_short | Transcutaneous measurement of glucose using Raman spectroscopy |
| title_sort | transcutaneous measurement of glucose using raman spectroscopy |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/27121 |
| work_keys_str_mv | AT ohjeankun1968 transcutaneousmeasurementofglucoseusingramanspectroscopy |