Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording
Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.
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| Format: | Thesis |
| Language: | en_US |
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Massachusetts Institute of Technology
2005
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| Online Access: | http://hdl.handle.net/1721.1/28864 |
| _version_ | 1811069987502161920 |
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| author | Vuong, Yihvan, 1981- |
| author2 | James J. Di Carlo. |
| author_facet | James J. Di Carlo. Vuong, Yihvan, 1981- |
| author_sort | Vuong, Yihvan, 1981- |
| collection | MIT |
| description | Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004. |
| first_indexed | 2024-09-23T08:20:05Z |
| format | Thesis |
| id | mit-1721.1/28864 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:20:05Z |
| publishDate | 2005 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/288642019-04-09T18:01:29Z Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording Vuong, Yihvan, 1981- James J. Di Carlo. Massachusetts Institute of Technology. Biological Engineering Division. Massachusetts Institute of Technology. Biological Engineering Division. Biological Engineering Division. Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004. Includes bibliographical references (leaf 43). (cont.) electrodes. Flexible multi-electrode arrays represent an evolving technology for chronic deep neuronal recording. We focus on developing a biocompatible method of implanting a novel 12-electrode device for long-term recording (weeks to months) in a deep target responsible for object identification, the inferotemporal cortex (IT). Numerous electrodes embedded in a bioerodible polymer matrix composed of 50/50 poly(D,L-lactide-co-glycolide) created an electrode bundle that was sufficiently stiff for insertion into brain tissue, but was expected to become more flexible after polymer degradation. Titanium electrode ports used to house these multi-electrode arrays were successfully designed, constructed, and implanted on a non-human primate as well. These ports were tested for mechanical durability over a course of 6-8 weeks. To evaluate the recording properties of the electrodes, many parameters of the electrode bundle tip were explored and evaluated, including gold-plating, tip cutting (flat cut, angle cut, or individual wire cut), and splaying. Gold-plating lowered electrode impedance and improved signal quality on originally high impedance electrodes. The angle cut and individually cut electrodes were superior to the flat cut ones; they recorded from 6-7 active channels at varying depths during advancement. Splaying, the removal of polymer some distance from the array tip to separate the bundle into individual electrodes, also improved the recording properties in acute experiments. Pending chronic experiments will further reveal 1) the true degradation rate of the array and thus the flexibility restored, 2) the electrode tip characteristics following polymer erosion, and 3) the long-term recording quality and stability of all the by Yihvan Vuong. M.Eng. 2005-09-27T18:45:47Z 2005-09-27T18:45:47Z 2004 2004 Thesis http://hdl.handle.net/1721.1/28864 60412322 en_US MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 43 leaves 3833473 bytes 3836276 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biological Engineering Division. Vuong, Yihvan, 1981- Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording |
| title | Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording |
| title_full | Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording |
| title_fullStr | Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording |
| title_full_unstemmed | Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording |
| title_short | Development of a biocompatible method of implanting multi-electrode arrays for stable chronic deep neuronal recording |
| title_sort | development of a biocompatible method of implanting multi electrode arrays for stable chronic deep neuronal recording |
| topic | Biological Engineering Division. |
| url | http://hdl.handle.net/1721.1/28864 |
| work_keys_str_mv | AT vuongyihvan1981 developmentofabiocompatiblemethodofimplantingmultielectrodearraysforstablechronicdeepneuronalrecording |