The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.
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| Format: | Thesis |
| Language: | en_US |
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Massachusetts Institute of Technology
2005
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| Online Access: | http://hdl.handle.net/1721.1/28867 |
| _version_ | 1826217148363571200 |
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| author | Eipper-Mains, Marcie A., 1979- |
| author2 | Jacqueline A. Lees. |
| author_facet | Jacqueline A. Lees. Eipper-Mains, Marcie A., 1979- |
| author_sort | Eipper-Mains, Marcie A., 1979- |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2004. |
| first_indexed | 2024-09-23T16:59:05Z |
| format | Thesis |
| id | mit-1721.1/28867 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:59:05Z |
| publishDate | 2005 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/288672019-04-11T09:44:50Z The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases Eipper-Mains, Marcie A., 1979- Jacqueline A. Lees. Massachusetts Institute of Technology. Dept. of Biology. Massachusetts Institute of Technology. Dept. of Biology. Biology. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2004. Includes bibliographical references (leaves [54]-[66]). The development of the immune system is a highly dynamic process, characterized by quickly and frequently changing cell types and numbers. The orchestration of cell growth and proliferation and also of cell death is a necessarily complex process, taking cues from a wide variety of sources. The nematode Caenorhabditus elegans has provided an elegant and simple model of the control of programmed cell death, or apoptosis, in metazoans. Apoptosis in mammals is regulated by pathways related to but more intricate than metazoans. Several key features define the onset of apoptosis in any given cell; these include DNA fragmentation and chromatin condensation, "blebbing" of the plasma membrane, and subsequent phagocytosis of the resulting cell fragments by adjacent cells (Kerr et al. 1972 and Wyllie et al. 1980). by Marcie A. Eipper-Mains. S.M. 2005-09-27T18:46:43Z 2005-09-27T18:46:43Z 2004 2004 Thesis http://hdl.handle.net/1721.1/28867 60412771 en_US M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 50, [16] leaves 4023616 bytes 4030350 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biology. Eipper-Mains, Marcie A., 1979- The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases |
| title | The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases |
| title_full | The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases |
| title_fullStr | The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases |
| title_full_unstemmed | The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases |
| title_short | The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases |
| title_sort | role of the bcl 2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases |
| topic | Biology. |
| url | http://hdl.handle.net/1721.1/28867 |
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