Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2005.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2008
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| Online Access: | http://dspace.mit.edu/handle/1721.1/28933 http://hdl.handle.net/1721.1/28933 |
| _version_ | 1811098015195201536 |
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| author | Harbison, Christopher T., 1973- |
| author2 | Richard A. Young. |
| author_facet | Richard A. Young. Harbison, Christopher T., 1973- |
| author_sort | Harbison, Christopher T., 1973- |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2005. |
| first_indexed | 2024-09-23T17:08:36Z |
| format | Thesis |
| id | mit-1721.1/28933 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T17:08:36Z |
| publishDate | 2008 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/289332019-04-13T00:10:09Z Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae Harbison, Christopher T., 1973- Richard A. Young. Massachusetts Institute of Technology. Dept. of Biology. Massachusetts Institute of Technology. Dept. of Biology. Biology. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2005. Includes bibliographical references. Historically, knowledge of gene-specific transcription has been accumulated by the study of the individual genetic and physical interactions between transcriptional regulators and the genes they regulate, often requiring considerable time and effort. Microarray technology now enables investigation of gene expression at the level of the entire genome, allowing researchers access to rich datasets and promising new levels of depth in the understanding of transcriptional regulation. Our lab has made use of these technologies both to measure the levels of all mRNA transcripts within a population of cells, as well as to locate the regions within the genome that are bound by transcriptional regulators. Such studies not only allow for the functional annotation of both genes and regulators, but can also provide clues about the identity of the regulatory regions within DNA, the structure of global regulatory networks and the regulation of DNA-binding proteins. These and other insights are presented here based on our genome-wide studies of transcriptional regulation in the yeast Saccharomyces cerevisiae. by Christopher T. Harbison. Ph.D. 2008-02-28T16:04:19Z 2008-02-28T16:04:19Z 2005 2005 Thesis http://dspace.mit.edu/handle/1721.1/28933 http://hdl.handle.net/1721.1/28933 60552283 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/28933 http://dspace.mit.edu/handle/1721.1/7582 228 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biology. Harbison, Christopher T., 1973- Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae |
| title | Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae |
| title_full | Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae |
| title_fullStr | Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae |
| title_full_unstemmed | Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae |
| title_short | Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae |
| title_sort | genome wide analysis of transcriptional expression programs regulatory networks and cis regulatory sequences in saccharomyces cerevisiae |
| topic | Biology. |
| url | http://dspace.mit.edu/handle/1721.1/28933 http://hdl.handle.net/1721.1/28933 |
| work_keys_str_mv | AT harbisonchristophert1973 genomewideanalysisoftranscriptionalexpressionprogramsregulatorynetworksandcisregulatorysequencesinsaccharomycescerevisiae |