Effects of in vivo degradation on mechanical behavior of a novel bioelastomer
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, June 2002.
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
| Published: |
Massachusetts Institute of Technology
2006
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1721.1/29587 |
| _version_ | 1811088043208081408 |
|---|---|
| author | Aronstam, Robert A. (Robert Andrew), 1979- |
| author2 | Mary C. Boyce. |
| author_facet | Mary C. Boyce. Aronstam, Robert A. (Robert Andrew), 1979- |
| author_sort | Aronstam, Robert A. (Robert Andrew), 1979- |
| collection | MIT |
| description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, June 2002. |
| first_indexed | 2024-09-23T13:55:21Z |
| format | Thesis |
| id | mit-1721.1/29587 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:55:21Z |
| publishDate | 2006 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/295872019-04-12T09:21:49Z Effects of in vivo degradation on mechanical behavior of a novel bioelastomer Effects of in vivo degradation on mechanical behavior of PSG Aronstam, Robert A. (Robert Andrew), 1979- Mary C. Boyce. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, June 2002. Includes bibliographical references (leaves 32-33). An experimental study was performed to record and model the stress-strain behavior of a novel bioelastomer (PSG) during five one-week intervals of in vivo degradation. Also of interest were the changes in compressive Young's modulus of due to the degradation. Samples of PSG were implanted in Sprague-Dawley rats, extracted after each interval, and tested on a compression testing machine. The stress-strain behavior of the PSG was recorded and compared to two theoretical models: a Gaussian model and an 8-chain (non-Gaussian) model. The 8-chain model yielded the better predictions for the highly nonlinear PSG stress-strain behavior. The compressive Young's modulus for PSG decreased significantly after the first week of degradation, but remained relatively stable for the final four weeks. The proportional change in volume due to in vivo degradation of PSG was less than that of PLGA, a widely-used bioelastomer. Additionally, the PSG maintained its physical shape much better than PLGA. by Robert A. Aronstam. S.B. 2006-03-24T16:05:06Z 2006-03-24T16:05:06Z 2003 2002 Thesis http://hdl.handle.net/1721.1/29587 52899235 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 33 leaves 1381552 bytes 1381359 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Aronstam, Robert A. (Robert Andrew), 1979- Effects of in vivo degradation on mechanical behavior of a novel bioelastomer |
| title | Effects of in vivo degradation on mechanical behavior of a novel bioelastomer |
| title_full | Effects of in vivo degradation on mechanical behavior of a novel bioelastomer |
| title_fullStr | Effects of in vivo degradation on mechanical behavior of a novel bioelastomer |
| title_full_unstemmed | Effects of in vivo degradation on mechanical behavior of a novel bioelastomer |
| title_short | Effects of in vivo degradation on mechanical behavior of a novel bioelastomer |
| title_sort | effects of in vivo degradation on mechanical behavior of a novel bioelastomer |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/29587 |
| work_keys_str_mv | AT aronstamrobertarobertandrew1979 effectsofinvivodegradationonmechanicalbehaviorofanovelbioelastomer AT aronstamrobertarobertandrew1979 effectsofinvivodegradationonmechanicalbehaviorofpsg |