A feedback analysis of outer hair cell dynamics
Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2006
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| Online Access: | http://hdl.handle.net/1721.1/29677 |
| _version_ | 1826205418791108608 |
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| author | Lu, Timothy K. (Timothy Kuan-Ta), 1981- |
| author2 | Rahul Sarpeshkar. |
| author_facet | Rahul Sarpeshkar. Lu, Timothy K. (Timothy Kuan-Ta), 1981- |
| author_sort | Lu, Timothy K. (Timothy Kuan-Ta), 1981- |
| collection | MIT |
| description | Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003. |
| first_indexed | 2024-09-23T13:12:23Z |
| format | Thesis |
| id | mit-1721.1/29677 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:12:23Z |
| publishDate | 2006 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/296772019-04-12T21:58:23Z A feedback analysis of outer hair cell dynamics Lu, Timothy K. (Timothy Kuan-Ta), 1981- Rahul Sarpeshkar. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003. Includes bibliographical references (leaves 144-146). Outer hair cells (OHCs) generate active forces in the mammalian cochlea. Acting as cochlear amplifiers, OHCs can counteract viscous drag, generating high gain at characteristic frequencies and allowing for the sharp frequency selectivity and sensitivity observed in mammals. Excitatory displacement of the basilar membrane causes depolarization of OHC membrane potentials which results in contraction. The motor protein prestin is driven by receptor potentials. However, low-pass filtering by the plasma membrane should severely attenuate the receptor potential at high frequencies (> 100 kHz) where mammalian hearing has been observed. Thus, an open question is how OHCs can respond at these high frequencies despite their low frequency cutoff. Inspired by the use of feedback in mechanical and electrical systems to accelerate slow poles, I demonstrate that negative feedback from the coupling of two mechanical modes of vibration can lead to a membrane time constant speedup and a sharpening of the mechanical response. y Timothy K. Lu. M.Eng.and S.B. 2006-03-24T16:14:19Z 2006-03-24T16:14:19Z 2003 2003 Thesis http://hdl.handle.net/1721.1/29677 53834016 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 146 leaves 5173220 bytes 5173026 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Lu, Timothy K. (Timothy Kuan-Ta), 1981- A feedback analysis of outer hair cell dynamics |
| title | A feedback analysis of outer hair cell dynamics |
| title_full | A feedback analysis of outer hair cell dynamics |
| title_fullStr | A feedback analysis of outer hair cell dynamics |
| title_full_unstemmed | A feedback analysis of outer hair cell dynamics |
| title_short | A feedback analysis of outer hair cell dynamics |
| title_sort | feedback analysis of outer hair cell dynamics |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/29677 |
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