Design and Evolution of Engineered Biological Systems
Poster presented at the 2005 ICSB meeting, held at Harvard Medical School in Boston, MA.
| Main Authors: | , , |
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| Format: | Presentation |
| Language: | en_US |
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Sixth International Conference on Systems Biology
2005
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| Online Access: | http://hdl.handle.net/1721.1/29799 |
| _version_ | 1826189304049696768 |
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| author | Kelly, Jason Michener, Josh Endy, Drew |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Kelly, Jason Michener, Josh Endy, Drew |
| author_sort | Kelly, Jason |
| collection | MIT |
| description | Poster presented at the 2005 ICSB meeting, held at Harvard Medical School in Boston, MA. |
| first_indexed | 2024-09-23T08:12:41Z |
| format | Presentation |
| id | mit-1721.1/29799 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2025-03-10T06:57:16Z |
| publishDate | 2005 |
| publisher | Sixth International Conference on Systems Biology |
| record_format | dspace |
| spelling | mit-1721.1/297992025-02-27T21:04:33Z Design and Evolution of Engineered Biological Systems Kelly, Jason Michener, Josh Endy, Drew Massachusetts Institute of Technology. Department of Biological Engineering evolution design Poster presented at the 2005 ICSB meeting, held at Harvard Medical School in Boston, MA. To date, engineered biological systems have been constructed via a variety of ad hoc approaches. The resulting systems should be thought of as pieces of art. We are interested in exploring how existing forward engineering approaches might be combined with directed evolution to make routine the construction of engineered biological systems. We have specified a procedure for construction of biological systems via screening of subcomponent libraries and rational re-assembly. We have begun development of tools to enable this approach, including a FACS-based screening system to rapidly measure the input/output function of a genetic circuit. Additionally, we have designed a microfluidic system that enables more sophisticated screening and selection functions. Specifically, a microfluidic chemostat integrated with a cell sorter (i.e., a sortostat). This microscope-based system will enable us to evaluate whether or not more complicated screens and selections will be of practical use in service of evolving engineered biological systems. 2005-11-29T16:32:11Z 2005-11-29T16:32:11Z 2005-10-20 Presentation http://hdl.handle.net/1721.1/29799 en_US 261079 bytes application/pdf application/pdf Sixth International Conference on Systems Biology |
| spellingShingle | evolution design Kelly, Jason Michener, Josh Endy, Drew Design and Evolution of Engineered Biological Systems |
| title | Design and Evolution of Engineered Biological Systems |
| title_full | Design and Evolution of Engineered Biological Systems |
| title_fullStr | Design and Evolution of Engineered Biological Systems |
| title_full_unstemmed | Design and Evolution of Engineered Biological Systems |
| title_short | Design and Evolution of Engineered Biological Systems |
| title_sort | design and evolution of engineered biological systems |
| topic | evolution design |
| url | http://hdl.handle.net/1721.1/29799 |
| work_keys_str_mv | AT kellyjason designandevolutionofengineeredbiologicalsystems AT michenerjosh designandevolutionofengineeredbiologicalsystems AT endydrew designandevolutionofengineeredbiologicalsystems |