Engineering the Interface Between Cellular Chassis and Integrated Biological Systems
Poster presented at the 2005 ICSB meeting, held at Harvard Medical School in Boston, MA.
| Main Authors: | , |
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| Format: | Other |
| Language: | en_US |
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2005
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| Online Access: | http://hdl.handle.net/1721.1/29802 |
| _version_ | 1826201951415566336 |
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| author | Canton, Bartholomew Endy, Drew |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Canton, Bartholomew Endy, Drew |
| author_sort | Canton, Bartholomew |
| collection | MIT |
| description | Poster presented at the 2005 ICSB meeting, held at Harvard Medical School in Boston, MA. |
| first_indexed | 2024-09-23T11:59:33Z |
| format | Other |
| id | mit-1721.1/29802 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2025-03-10T10:18:17Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | mit-1721.1/298022025-02-27T21:05:21Z Engineering the Interface Between Cellular Chassis and Integrated Biological Systems Canton, Bartholomew Endy, Drew Massachusetts Institute of Technology. Department of Biological Engineering Synthetic Biology Engineered Biological Systems Biological Virtual Machines Cellular Chassis Poster presented at the 2005 ICSB meeting, held at Harvard Medical School in Boston, MA. The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help enable the future engineering of biological systems, we are studying and optimizing the interface between an engineered biological system and its host cell or ``chassis''. Other engineering disciplines use modularity to make interacting systems interchangeable and to insulate one system from another. Engineered biological systems are more likely to work as predicted if system function is decoupled from the state of the host cell. Also, specifying and standardizing the interfaces between a system and the chassis will allow systems to be engineered independent of chassis and allow systems to be interchanged between different chassis. To this end, we have assembled orthogonal transcription and translation systems employing dedicated machinery, independent from the equivalent host cell machinery. In parallel, we are developing test systems and metrics to measure the interactions between an engineered system and its chassis. Lastly, we are exploring methods to``port'' a simple engineered system from a prokaryotic to a eukaryotic organism so that the system can function in both organisms. 2005-12-06T20:05:18Z 2005-12-06T20:05:18Z 2005-10-21 Other http://hdl.handle.net/1721.1/29802 B. Canton and D. Endy. Engineering the Interface Between Cellular Chassis and Integrated Biological Systems. Sixth International Conference on Systems Biology, 2005. en_US 1915016 bytes application/pdf application/pdf |
| spellingShingle | Synthetic Biology Engineered Biological Systems Biological Virtual Machines Cellular Chassis Canton, Bartholomew Endy, Drew Engineering the Interface Between Cellular Chassis and Integrated Biological Systems |
| title | Engineering the Interface Between Cellular Chassis and Integrated Biological Systems |
| title_full | Engineering the Interface Between Cellular Chassis and Integrated Biological Systems |
| title_fullStr | Engineering the Interface Between Cellular Chassis and Integrated Biological Systems |
| title_full_unstemmed | Engineering the Interface Between Cellular Chassis and Integrated Biological Systems |
| title_short | Engineering the Interface Between Cellular Chassis and Integrated Biological Systems |
| title_sort | engineering the interface between cellular chassis and integrated biological systems |
| topic | Synthetic Biology Engineered Biological Systems Biological Virtual Machines Cellular Chassis |
| url | http://hdl.handle.net/1721.1/29802 |
| work_keys_str_mv | AT cantonbartholomew engineeringtheinterfacebetweencellularchassisandintegratedbiologicalsystems AT endydrew engineeringtheinterfacebetweencellularchassisandintegratedbiologicalsystems |