HIV entry : a biophysical and mutational analysis of gp41-mediated membrane fusion and its inhibition

HIV entry : a biophysical and mutational analysis of gp41-mediated membrane fusion and its inhibition

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2005.

Bibliographic Details
Main Author:	Suntoke, Tara R
Other Authors:	Peter S. Kim and David C. Chan.
Format:	Thesis
Language:	eng
Published:	Massachusetts Institute of Technology 2006
Subjects:	Biology.
Online Access:	http://hdl.handle.net/1721.1/31181

Similar Items

Development of HIV-1 fusion inhibitors targeting gp41
by: Lu, K., et al.
Published: (2014)

Inhibiting HIV-1 entry : utilizing a transient intermediate of viral membrane fusion as a target for drug discovery
by: Eckert, Debra M. (Debra Muir), 1973-
Published: (2005)

ADS-J21 is a novel HIV-1 entry inhibitor targeting gp41
by: Ruiying Liang, et al.
Published: (2024-01-01)

A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies
by: Evan M. Cale, et al.
Published: (2024-12-01)

Equations of membrane biophysics/
by: 236742 Lakshminarayanaiah, N
Published: (1984)

Solid-state NMR investigation of viral fusion glycoprotein 41 (gp41)
by: Morgan, Chloe A.(Chloe Anne)
Published: (2020)

Thermal biophysics of membranes /
by: 408388 Heimburg, Thomas
Published: (2007)

Cholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization.
by: Apellániz, B, et al.
Published: (2014)

Epitope exposure on functional, oligomeric HIV-1 gp41 molecules.
by: Sattentau, Q, et al.
Published: (1995)

Interactions of HIV gp41's membrane-proximal external region and transmembrane domain with phospholipid membranes from 31P NMR
by: Sutherland, Madeleine, et al.
Published: (2022)

SOLUBLE CD4 BINDING TO HIV-1 VIRIONS CAUSES GP120 TO DISSOCIATE FROM GP41
by: Moore, J, et al.
Published: (1991)

Crystal structure of a mutation in the HIV gp41 core : effect on a deep cavity and implication for drug development
by: Cameros, Brian (Brian Leigh), 1971-
Published: (2014)

Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins
by: Zhang, Si Min, et al.
Published: (2015)

Cell Surface-Expressed GPI-Anchored Peptides from the CHR Domain of gp41 Are Potent Inhibitors of HIV-1 Fusion
by: Aleksandra Maslennikova, et al.
Published: (2020-06-01)

Oligomeric structure and three-dimensional fold of the HIV gp41 membrane-proximal external region and transmembrane domain in phospholipid bilayers
by: Kwon, Byungsu, et al.
Published: (2020)

Adsorption and folding dynamics of MPER of HIV-1 gp41 in the presence of dpc micelle
by: Hartono, Yossa Dwi, et al.
Published: (2013)

Reverse Immunology Approach to Define a New HIV-gp41-Neutralizing Epitope
by: Karim Dorgham, et al.
Published: (2019-01-01)

Membrane structural biology : with biochemical and biophysical foundations /
by: 230579 Luckey, Mary
Published: (2008)

The Gp41 Sequence Connecting Mper and Tm Domains Constitutes a Distinct HIV-1 "Fusion Peptide" Targeted by Neutralizing Antibodies
by: Apellaniz, B, et al.
Published: (2014)

Biophysical techniques /
by: 350082 Campbell, Iain D.
Published: (c201)

Studies on the inhibition of viral entry of flaviviruses
by: Ravikumar Rajamanonmani
Published: (2011)

Membrane cholesterol regulates the oligomerization and fusogenicity of SARS-CoV fusion peptide: implications in viral entry
by: Meher, Geetanjali, et al.
Published: (2023)

Structural and biophysical characterization of membrane-coating proteins from the nuclear pore and the primary cilium
by: Knockenhauer, Kevin E. (Kevin Edward)
Published: (2016)

Membranes, ions and impulses : a chapter of classical biophysics/
by: Cole, Kenneth Stewart, 1900-
Published: (1972)

Fully Hydrophobic HIV gp41 Adopts a Hemifusion-Like Conformation in Phospholipid Bilayers
by: Lee, Myungwoon, et al.
Published: (2022)

GP96 and the immune response
by: Flynn, Karen Mildred Ryan, 1969-
Published: (2005)

Molecular biophysics /
by: Setlow, Richard B. (Richard Burton), et al.
Published: (1962)

Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds
by: Oakes, V, et al.
Published: (2018)

Molecular biophysics /
by: Volkenshtein, M. V. (Mikhail Vladimirovich), 1912-
Published: (1977)

Computational study of bindings of HK20 Fab and D5 Fab to HIV-1 gp41
by: Hartono, Yossa Dwi, et al.
Published: (2013)

Enriching for HIV-infected cells using anti-gp41 antibodies indirectly conjugated to magnetic microbeads
by: Bouchaib Bahbouhi, et al.
Published: (2004-01-01)

On the whereabouts of HIV-1 cellular entry and its fusion ports
by: Jakobsdottir, G, et al.
Published: (2017)

HIV-1 entry inhibition capabilities of Isoflavones
by: Mr Steven Raubenheimer, et al.
Published: (2025-03-01)

Molecular and cellular biophysics /
by: 244608 Tuszynski, Jack A.
Published: (2008)

Molecular biophysics : structures in motion /
by: 384038 Daune, Michel
Published: (1999)

Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity
by: Donius, Luke R., et al.
Published: (2017)

Lipids & membrane biophysics : Burlington House, London, UK 11-13 September 2012
Published: (2013)

Conformational Dynamics Related to Membrane Fusion Observed in Single Ebola GP Molecules
by: Dibyendu Kumar Das, et al.
Published: (2020-06-01)

Conformational Dynamics Related to Membrane Fusion Observed in Single Ebola GP Molecules
by: Dibyendu Kumar Das, et al.
Published: (2020-06-01)

Biophysical and structural aspects of bioenergetics /
by: Wikstrom, Marten
Published: (2005)