Intrinsic constraints on cross-modal plasticity
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2004.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2006
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| Online Access: | http://hdl.handle.net/1721.1/32516 |
| _version_ | 1811084304726360064 |
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| author | Ellsworth, Charlene |
| author2 | Mriganka Sur. |
| author_facet | Mriganka Sur. Ellsworth, Charlene |
| author_sort | Ellsworth, Charlene |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2004. |
| first_indexed | 2024-09-23T12:48:37Z |
| format | Thesis |
| id | mit-1721.1/32516 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T12:48:37Z |
| publishDate | 2006 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/325162019-04-12T12:58:46Z Intrinsic constraints on cross-modal plasticity Ellsworth, Charlene Mriganka Sur. Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. Brain and Cognitive Sciences. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2004. Includes bibliographical references (p. 120-125). Over the last two decades numerous examples have demonstrated the remarkable plasticity of the developing brain. This plasticity occurs from the level of a single synapse to the repatterning of sensory input. One paradigm that demonstrates this plasticity is the re-routing of sensory input to inappropriate targets. This cross-modal plasticity in an animal model is reminiscent of similar rearrangements in deaf and blind human patients. In these animal models, visual input is induced to innervate the auditory or somatosensory thalamus, MGN and VB respectively, as a result of deafferentation of these nuclei. Such experiments have demonstrated that structures are influenced by their input, and therefore sensory input is able to use alternative pathways for function. This thesis examines the extent to which cues intrinsic to the target provide information to these novel retino-MGN projections. It will consider two examples in which the target structure imposes order onto the incoming sensory input; via intra-nuclei patterning and via a behaviorally relevant efferent pathway. We demonstrate that retinal axons use an ephrin gradient present in the MGN to acquire orderly connections, akin to retinal patterning in visual targets. Using fear conditioning, we show that learning of a visual cue changes when visual input is routed through the auditory pathway. To better understand the intrinsic cues present in a target, we identify a set of genes differentially expressed in the LGN and MGN, which includes a list of transcription factors and putative downstream targets. (cont.) Furthermore, we demonstrate that deafferentation of the MGN does not influence these sensory-specific molecular profiles but does create a permissive environment which induces innervation by local axons. by Charlene Ellsworth. Ph.D. 2006-03-29T18:51:45Z 2006-03-29T18:51:45Z 2004 2004 Thesis http://hdl.handle.net/1721.1/32516 62075212 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 125 p. 7580418 bytes 7586646 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Brain and Cognitive Sciences. Ellsworth, Charlene Intrinsic constraints on cross-modal plasticity |
| title | Intrinsic constraints on cross-modal plasticity |
| title_full | Intrinsic constraints on cross-modal plasticity |
| title_fullStr | Intrinsic constraints on cross-modal plasticity |
| title_full_unstemmed | Intrinsic constraints on cross-modal plasticity |
| title_short | Intrinsic constraints on cross-modal plasticity |
| title_sort | intrinsic constraints on cross modal plasticity |
| topic | Brain and Cognitive Sciences. |
| url | http://hdl.handle.net/1721.1/32516 |
| work_keys_str_mv | AT ellsworthcharlene intrinsicconstraintsoncrossmodalplasticity |