The development of an in vitro, one-pass, high-throughput model of flow dependent thrombosis
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.
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| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2006
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| Online Access: | http://hdl.handle.net/1721.1/32861 |
| _version_ | 1811090069938765824 |
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| author | Echenique, Javier Jacobo |
| author2 | Elazer R. Edelman. |
| author_facet | Elazer R. Edelman. Echenique, Javier Jacobo |
| author_sort | Echenique, Javier Jacobo |
| collection | MIT |
| description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005. |
| first_indexed | 2024-09-23T14:32:14Z |
| format | Thesis |
| id | mit-1721.1/32861 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:32:14Z |
| publishDate | 2006 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/328612019-04-11T01:19:09Z The development of an in vitro, one-pass, high-throughput model of flow dependent thrombosis Echenique, Javier Jacobo Elazer R. Edelman. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005. Includes bibliographical references (leaves 43-46). Thrombosis is an initiating response to a vascular injury, which aids in the repair and remodeling of the vessel wall. However, if this process remains unchecked, occlusion of the arterial lumen may quickly occur. The arterial vascular bed is a delicate and life-sustaining environment, in which a pathological thrombosis can bring about devastating conclusions such as acute vascular syndromes or post-interventional thrombosis. In order to explore these flow-dependent thrombotic reactions, it is essential to consider the physical environment present inside the vasculature. A novel in vitro, high-throughput method for creating one-pass blood flows has been developed to model the arterial environment. Flow is generated in a matrix of small glass tubes with varying inner diameters through the use of a constant pressure drop. Using this technique, a variety of flow rates are created in the numerous tubes, resulting in a variety of flow shear rates. In addition, this technique allows for the monitoring of sensitive, flow-dependent processes without the disturbances from pump action and circuit effects. A detailed discussion about the goals of the proposed systems is included, as well as the methodology employed to choose the optimal flow system, and the process by which the components of the system evolved in design. (cont.) Finally, tests are formulated in order to explore the issues of biological feasibility, noise, precision, and accuracy related to the proposed system and make to make improvements on the design accordingly. by Javier Jacobo Echenique. S.B. 2006-05-15T20:35:18Z 2006-05-15T20:35:18Z 2005 2005 Thesis http://hdl.handle.net/1721.1/32861 62587413 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 46 leaves 3500984 bytes 3501217 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Echenique, Javier Jacobo The development of an in vitro, one-pass, high-throughput model of flow dependent thrombosis |
| title | The development of an in vitro, one-pass, high-throughput model of flow dependent thrombosis |
| title_full | The development of an in vitro, one-pass, high-throughput model of flow dependent thrombosis |
| title_fullStr | The development of an in vitro, one-pass, high-throughput model of flow dependent thrombosis |
| title_full_unstemmed | The development of an in vitro, one-pass, high-throughput model of flow dependent thrombosis |
| title_short | The development of an in vitro, one-pass, high-throughput model of flow dependent thrombosis |
| title_sort | development of an in vitro one pass high throughput model of flow dependent thrombosis |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/32861 |
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