Biomechanical properties of engineered collagen scaffolds
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.
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| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2006
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| Online Access: | http://hdl.handle.net/1721.1/32876 |
| _version_ | 1811078534510149632 |
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| author | Bonebreak, Christina M. (Christina Michelle) |
| author2 | Simona Socrate. |
| author_facet | Simona Socrate. Bonebreak, Christina M. (Christina Michelle) |
| author_sort | Bonebreak, Christina M. (Christina Michelle) |
| collection | MIT |
| description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005. |
| first_indexed | 2024-09-23T11:01:43Z |
| format | Thesis |
| id | mit-1721.1/32876 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:01:43Z |
| publishDate | 2006 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/328762019-04-11T09:04:05Z Biomechanical properties of engineered collagen scaffolds Bonebreak, Christina M. (Christina Michelle) Simona Socrate. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005. Includes bibliographical references (leaves 33-35). An experiment was performed to determine the effect of crosslinking on the stiffness of collagen scaffolds. Engineered non-crosslinked and dehydrothermally crosslinked chondroitin-6-sulfate collagen scaffolds were hydrated and loaded in tension, and their mechanical properties were compared. It was found that non-crosslinked scaffolds experience an average increase in weight after hydration of 10,353%, compared to 7,265% for crosslinked scaffolds. Hyperelastic material parameters were determined by the Arruda-Boyce eight-chain model, which was fit to the experimental data. This model predicted an average number of rigid links per collagen fiber of 1.3 and 1.21 for crosslinked and non-crosslinked scaffolds, respectively. Additionally, the collagen fiber densities were found to be 2.92 x 1017 for crosslinked networks and 1.68 x 1017 for non-crosslinked networks. These results can be applied to the changes that take place in the cervix at the onset of delivery. It is hypothesized that the crosslinking between collagen fibers in the cervix breaks down during preparation for delivery, allowing more fluid to enter the extracellular matrix and weaken the tissue. By performing tension tests on cervix tissue in vivo, one can produce a theoretical fit to predict relevant collagen network parameters, which can be compared with those of non-pregnant cervical tissue to indicate the early onset of cervical ripening. (cont.) By being able to quantitatively assess a woman's risk of early cervical ripening, it may be possible to prevent premature births associated with cervical insufficiency. by Christina M. Bonebreak. S.B. 2006-05-15T20:36:21Z 2006-05-15T20:36:21Z 2005 2005 Thesis http://hdl.handle.net/1721.1/32876 62588716 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 35 leaves 2188306 bytes 2187505 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Bonebreak, Christina M. (Christina Michelle) Biomechanical properties of engineered collagen scaffolds |
| title | Biomechanical properties of engineered collagen scaffolds |
| title_full | Biomechanical properties of engineered collagen scaffolds |
| title_fullStr | Biomechanical properties of engineered collagen scaffolds |
| title_full_unstemmed | Biomechanical properties of engineered collagen scaffolds |
| title_short | Biomechanical properties of engineered collagen scaffolds |
| title_sort | biomechanical properties of engineered collagen scaffolds |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/32876 |
| work_keys_str_mv | AT bonebreakchristinamchristinamichelle biomechanicalpropertiesofengineeredcollagenscaffolds |