Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2006
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| Online Access: | http://hdl.handle.net/1721.1/32886 |
| _version_ | 1826193925819334656 |
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| author | Hsu, Jeffrey J |
| author2 | Roger D. Kamm and Mohammad R. Kaazempur-Mofrad. |
| author_facet | Roger D. Kamm and Mohammad R. Kaazempur-Mofrad. Hsu, Jeffrey J |
| author_sort | Hsu, Jeffrey J |
| collection | MIT |
| description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005. |
| first_indexed | 2024-09-23T09:47:10Z |
| format | Thesis |
| id | mit-1721.1/32886 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T09:47:10Z |
| publishDate | 2006 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/328862019-04-12T20:16:52Z Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations Viscoelastic 2-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations Viscoelastic 2D modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations Hsu, Jeffrey J Roger D. Kamm and Mohammad R. Kaazempur-Mofrad. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005. "June 2005." Includes bibliographical references (p. 41-43). Introduction: Cells are exposed to a wide variety of forces within the human body, and the mechanisms by which cells respond to these forces are largely unknown. From altering gene transcription in the cell nucleus to conformational changes in membrane channel proteins that lead to increased or decreased ion permeability, external stresses imposed on the cell can significantly affect cellular actions through a process known as "mechanotransduction." While such cellular actions include fundamental processes such as cell motility and protein production, the cellular response to external forces can also be pathogenic. For instance, plaque formation within the arteries often occurs at points where the arteries branch or bend sharply, or rather, where cells are subjected to low or reversing fluid shear stresses. by Jeffrey J. Hsu. S.B. 2006-05-15T20:37:01Z 2006-05-15T20:37:01Z 2005 Thesis http://hdl.handle.net/1721.1/32886 62616334 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 43 p. 1971024 bytes 1971003 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Hsu, Jeffrey J Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations |
| title | Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations |
| title_full | Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations |
| title_fullStr | Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations |
| title_full_unstemmed | Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations |
| title_short | Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations |
| title_sort | viscoelastic two dimensional modeling of cell deformation due to shear stress on apical focal adhesion with experimental design considerations |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/32886 |
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