Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery
Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2005.
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
| Published: |
Massachusetts Institute of Technology
2008
|
| Subjects: | |
| Online Access: | http://dspace.mit.edu/handle/1721.1/33070 http://hdl.handle.net/1721.1/33070 |
| _version_ | 1824457836209373184 |
|---|---|
| author | Connor, Christopher W |
| author2 | Kullervo Hynynen. |
| author_facet | Kullervo Hynynen. Connor, Christopher W |
| author_sort | Connor, Christopher W |
| collection | MIT |
| description | Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2005. |
| first_indexed | 2024-09-23T11:02:49Z |
| format | Thesis |
| id | mit-1721.1/33070 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:02:49Z |
| publishDate | 2008 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/330702019-04-10T16:25:43Z Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery Connor, Christopher W Kullervo Hynynen. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology. Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2005. Includes bibliographical references. Many brain tumors are localized deeply and are currently surgically inaccessible without causing severe damage to the overlying structures of the brain. The current spectrum of non-invasive methods for treating such tumors includes radiotherapy, which requires exposure to ionizing radiation, and chemotherapy, which is systemically toxic. However, these tumors may also potentially be attacked by focusing highly intense ultrasound onto them. Focused ultrasound surgery is without the side effects of radiotherapy and chemotherapy, and the therapeutic effect of ultrasound therapy can be monitored in real- time using the proton chemical shift MRI technique. However, in order for brain tumors to be treated non-invasively, the ultrasound must be focused onto the targeted brain tissue through the intact cranium. Transcranial focusing of ultrasound is a longstanding and difficult problem as skull is a highly heterogeneous material. As the ultrasound field propagates through the bones of the skull, it undergoes substantatial distortion due to the variations in density and speed of sound therein. There is substantial individual variation in skull size, thickness and composition. Furthermore, the acoustic attenuation coefficient in bone is high, so the skull may also be heated by the ultrasound propagating through it. This thesis contains novel simulation techniques for analyzing transcranial acoustic propagation and for analyzing the temperature changes so produced in the brain, skull and scalp. These techniques have also been applied to modeling non-invasive treatment of the liver, and to producing therapeutic ultrasound fields that harness non-linear acoustic effects advantageously. (cont.) The thesis also contains unified models for the speed of sound and the acoustic attenuation coeffiecient in human skull. These models were generated by combining genetic optimization algorithms, acoustic propagation modeling and empirical measurement of intracranial ultrasound fields; they are valid across the full range of trabecular and cortical cranial bone. by Christopher W. Connor. Ph.D. 2008-02-28T16:11:32Z 2008-02-28T16:11:32Z 2005 2005 Thesis http://dspace.mit.edu/handle/1721.1/33070 http://hdl.handle.net/1721.1/33070 62147357 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/33070 http://dspace.mit.edu/handle/1721.1/7582 300 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Harvard University--MIT Division of Health Sciences and Technology. Connor, Christopher W Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery |
| title | Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery |
| title_full | Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery |
| title_fullStr | Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery |
| title_full_unstemmed | Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery |
| title_short | Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery |
| title_sort | simulation methods and tissue property models for non invasive transcranial focused ultrasound surgery |
| topic | Harvard University--MIT Division of Health Sciences and Technology. |
| url | http://dspace.mit.edu/handle/1721.1/33070 http://hdl.handle.net/1721.1/33070 |
| work_keys_str_mv | AT connorchristopherw simulationmethodsandtissuepropertymodelsfornoninvasivetranscranialfocusedultrasoundsurgery |