Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2006.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2008
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| Online Access: | http://dspace.mit.edu/handle/1721.1/34484 http://hdl.handle.net/1721.1/34484 |
| _version_ | 1811089347614605312 |
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| author | Krupa, Boris |
| author2 | Guosong Liu. |
| author_facet | Guosong Liu. Krupa, Boris |
| author_sort | Krupa, Boris |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2006. |
| first_indexed | 2024-09-23T14:17:45Z |
| format | Thesis |
| id | mit-1721.1/34484 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:17:45Z |
| publishDate | 2008 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/344842019-04-10T12:27:53Z Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission Effects of the release time course of neurotransmitter on synaptic transmission Krupa, Boris Guosong Liu. Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. Brain and Cognitive Sciences. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2006. Includes bibliographical references. Introduction: This thesis contains two main projects that I worked on during my graduate studies at MIT. Both address the subject matter of how neurons communicate, process, and pass information within the context of larger neuronal ensembles. The first project focuses on information transfer between two neurons during synaptic transmission. The project was spurred by an initial observation that neuronal communication through synapses in young and developing neuronal networks is only "half-hearted" in that signals propagate predominantly through only one type of synaptic receptor (the NMDA receptor), and bypass the principal signaling pathway present in mature synaptic transmission (AMPA receptor) (Malenka and Nicoll 1997). The possible cause of this abnormality was either that AMPA receptors were lacking on the postsynaptic side, or that something else in the process of synaptic transmission rendered them inoperable. by Boris Krupa. Ph.D. 2008-02-28T16:24:13Z 2008-02-28T16:24:13Z 2006 2006 Thesis http://dspace.mit.edu/handle/1721.1/34484 http://hdl.handle.net/1721.1/34484 70785940 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/34484 http://dspace.mit.edu/handle/1721.1/7582 [77] p. in various pagings application/pdf Massachusetts Institute of Technology |
| spellingShingle | Brain and Cognitive Sciences. Krupa, Boris Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission |
| title | Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission |
| title_full | Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission |
| title_fullStr | Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission |
| title_full_unstemmed | Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission |
| title_short | Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission |
| title_sort | dendritic sensitivity to the direction of synaptic firing mediated by inhibition and the effects of the release timecourse of neurotransmitter on synaptic transmission |
| topic | Brain and Cognitive Sciences. |
| url | http://dspace.mit.edu/handle/1721.1/34484 http://hdl.handle.net/1721.1/34484 |
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