Assembly and functionalization of phage onto substrates patterned by dip-pen nanolithography
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2006
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| Online Access: | http://hdl.handle.net/1721.1/35069 |
| _version_ | 1826206872806359040 |
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| author | Gray, David Steven |
| author2 | Angela M. Belcher. |
| author_facet | Angela M. Belcher. Gray, David Steven |
| author_sort | Gray, David Steven |
| collection | MIT |
| description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006. |
| first_indexed | 2024-09-23T13:39:33Z |
| format | Thesis |
| id | mit-1721.1/35069 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:39:33Z |
| publishDate | 2006 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/350692019-04-11T13:17:49Z Assembly and functionalization of phage onto substrates patterned by dip-pen nanolithography Gray, David Steven Angela M. Belcher. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Materials Science and Engineering. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006. Includes bibliographical references (leaves 25-26). Advances in nanochemistry will drive the development of technologies at the scale of 1 - 100 nm. Principles of biology are used for the self-assembly of structures and devices at this scale. The Ml 13 bacteriophage, a virus employed in phage-display libraries, serves as a scaffold for nanoscale structures. Phage are functionalized with inorganic materials, and controlled placement of phage at the nanoscale may lead to useful devices. Substrates patterned with dip-pen nanolithography (DPN) serve as templates for the deposition of phage. On gold substrates, 16-mercaptohexadecanoic acid (MHA) is deposited to form patterned lines. After surface passivation and activation chemistry, phage are deposited and adhere to the patterned substrate. Images from atomic force microscopy support that phage are covalently coupled to MHA lines and that cobalt precipitates on patterned phage. by David S. Gray. S.B. 2006-12-18T20:01:57Z 2006-12-18T20:01:57Z 2006 2006 Thesis http://hdl.handle.net/1721.1/35069 71230730 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 26 leaves 1422574 bytes 1420983 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Materials Science and Engineering. Gray, David Steven Assembly and functionalization of phage onto substrates patterned by dip-pen nanolithography |
| title | Assembly and functionalization of phage onto substrates patterned by dip-pen nanolithography |
| title_full | Assembly and functionalization of phage onto substrates patterned by dip-pen nanolithography |
| title_fullStr | Assembly and functionalization of phage onto substrates patterned by dip-pen nanolithography |
| title_full_unstemmed | Assembly and functionalization of phage onto substrates patterned by dip-pen nanolithography |
| title_short | Assembly and functionalization of phage onto substrates patterned by dip-pen nanolithography |
| title_sort | assembly and functionalization of phage onto substrates patterned by dip pen nanolithography |
| topic | Materials Science and Engineering. |
| url | http://hdl.handle.net/1721.1/35069 |
| work_keys_str_mv | AT graydavidsteven assemblyandfunctionalizationofphageontosubstratespatternedbydippennanolithography |